中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (34): 6389-6392.doi: 10.3969/j.issn.1673-8225.2010.34.029

• 生物材料综述 biomaterial review • 上一篇    下一篇

受损心肌组织工程修复材料的血管化

沈  楠1，2，沈  阳1，刘肖珩1   

  1. 1 四川大学华西基础医学与法医学院生物医学工程研究室，四川省成都市   610045；2 四川大学生命科学学院，四川省成都市   610045
  • 出版日期:2010-08-20 发布日期:2010-08-20
  • 通讯作者: 刘肖珩，教授，博士生导师，四川大学华西基础医学与法医学院生物医学工程教研室，四川省成都市 610045 liuxiaohg@sina.com.cn
  • 作者简介:沈楠，女，1989 年生，安徽省马鞍山市人，汉族，四川大学生命科学学院本科在读。 Nicolebio7@gmail.com

Vascularization of tissue engineered repair materials for damaged myocardium

Shen Nan 1,2, Shen Yang1, Liu Xiao-heng1   

  1. 1 Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu   610045, Sichuan Province, China; 2 School of Life Science, Sichuan University, Chengdu   610045, Sichuan Province, China 
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Liu Xiao-heng, Professor, Doctoral supervisor, Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610045, Sichuan Province, China liuxiaohg@sina.com.cn
  • About author:Shen Nan, Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610045, Sichuan Province, China; School of Life Science, Sichuan University, Chengdu 610045, Sichuan Province, China Nicolebio7@gmail.com

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402

被引次数

3

摘要：

背景：心肌组织缺乏再生能力，受损后通过组织工程方法进行修复，而血管化在修复中起着重要作用。
目的：就受损心肌组织工程修复的支架材料设计、输送血管生长因子、体内预血管化和体外预血管化等方面的最新研究进展进行综述。
方法：以“Vascularization; Myocardium; Tissue Engineering; Regeneration Medicine”为检索词，应用计算机检索1995-01/2010-04 Sciencedirect数据库和Archive of Issues Nature数据库，检索到文献150篇，保留32篇进行分析。
结果与结论：支架的结构、成分和物理性质影响着血管化的速度以及新生血管的完整性和功能。合理添加各种不同的血管生成因子能加快血管化进程。目前的研究表明，体内预血管化是最高效的，但患者需要承受两次外科手术和部分血管缺失。体外预血管化技术风险小，但普通医院无法满足苛刻的培养条件。另外，有必要建立一种能模拟体内微环境并且没有异源物质的基质。直至今日，所有模型都只能达到微米级的厚度，离真正的临床治疗还有很远的差距。

关键词: 心肌层, 组织工程, 血管化, 血管生长因子, 综述文献

Abstract:

BACKGROUND: Myocardium is weak in regenerating, making tissue engineering the top treatment after infarction. Thereby, vascularization plays a crucial role in the progress of repair.
OBJECTIVE: To summarize the research progress of tissue engineered repair for damaged myocardium from the perspectives of scaffold design, vascular growth factor delivery, in vivo prevascularization and in vitro prevascularization.
METHODS: Using “Vascularization; Myocardium; Tissue Engineering; Regeneration Medicine” as the key words, a computer research was performed in Sciencedirect database and Archive of Issues Nature database between January 1995 and April 2010. Totally 150 articles were screened out and 32 of them were involved in the analysis.
RESULTS AND CONCLUSION: The structure, composition and physical features of the scaffolds play a vital part in the process of vascularization, mainly expressed in the speed of vascularization, the integrity and function of new vessels. A variety of vascular growth factors serve various roles in different stages of the angiogenesis process. Current research shows that in vivo pre-vascularization is the most efficient, but patients have to bear second surgeries and some vascular loss. In vitro pre-vascularization provides graft tissues with central vessels, thus immediately realizing blood supply, but In vitro pre-vascularization requires high demand of the culture environment, which is difficult to meet in general hospitals. In addtion, it is necessary to establish a matrix without heterogeneous materials, preferably simulating in vivo micro-environment. Untile now, all models can only achieve micron-level thickness, leaving a long gap from the practical clinical therapy.

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