中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (16): 2911-2915.doi: 10.3969/j.issn.1673-8225.2010.16.016

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

口腔修复膜材料在牙种植中引导骨再生的效应

谢苗苗1，赵保东1，王维英1，于  龙2，张晓奇2   

  1. 1青岛大学医学院附属医院口腔科，山东省青岛市  266000；2烟台正海生物技术有限公司，山东省烟台市  264000
  • 出版日期:2010-04-16 发布日期:2010-04-16
  • 通讯作者: 赵保东，硕士，教授，硕士生导师，主任医师，青岛大学医学院附属医院口腔科，山东省青岛市 266000
  • 作者简介:谢苗苗★，女，1982年生，山东省青岛市人，汉族，青岛大学医学院在读硕士，主要从事口腔种植的研究。 anne00007@163.com

Effects of oral biofilm on guided bone regeneration in dental implant

Xie Miao-miao1, Zhao Bao-dong1, Wang Wei-ying1, Yu Long2, Zhang Xiao-qi2   

  1. 1 Department of Stomatology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao  266000, Shandong Province, China; 2 Yantai Zhenghai Bio-Technology  Co., Ltd., Yantai  264000, Shandong Province, China
  • Online:2010-04-16 Published:2010-04-16
  • Contact: Zhao Bao-dong, Master, Professor, Master’s supervisor, Chief physician, Department of Stomatology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266000, Shandong Province, China
  • About author:Xie Miao-miao★, Studying for master’s degree, Department of Stomatology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266000, Shandong Province, China anne00007@163.com

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摘要：

背景：海奥口腔修复膜作为可降解的脱细胞真皮基质，是用于修复口腔黏膜及软组织缺损的材料，由于具有可降解、易于制备、保存时间长、运输和贮存方便、成骨效果好等优点，现在也已开始作为引导骨再生材料用于种植。
目的：验证海奥口腔修复膜在种植中作为屏障膜引导骨再生的临床效果。
方法：选择种植术区存在骨缺损的患者72例，均为单颗牙缺失，按随机原则分为对照组和试验组，分别采用博特医用胶原膜和海奥口腔修复膜行“引导性骨再生”技术修复骨缺损。骨移植物均为天博骨粉，术后1，3个月进行X射线检查及临床检查。二期手术时，对新生骨组织量进行评估。
结果与结论：二期手术时，72例患者的种植体均已与骨组织形成骨结合，试验组平均骨生长效果为92%，对照组平均骨生长效果为91%，所有种植体均顺利完成种植义齿修复。修复后随访3~24个月，种植体均能成功地恢复咬合功能。结果提示海奥口腔修复膜在牙种植中引导骨再生的效果与博特医用胶原膜相当，在临床上可以作为骨再生引导膜使用。

关键词: 引导骨再生, 种植体, 屏障膜, 骨生长效果, 口腔生物材料

Abstract:

BACKGROUND: Heal-all oral biofilm is a material utilized in repairing oral mucosa and soft tissues defects and characterized by degradation, easily preparation, long preserved duration, convenient transportation and good ossification, which has been widely used in dental implant as guided bone regeneration materials.
OBJECTIVE: To check the clinical effective of Heal-all oral biofilm on guided bone regeneration in dental implant.
METHODS: A total of 72 patients with bone defects in the implantation area were selected as subjects, who were divided into control group and experimental group at random. Bone defects around implants were repaired by guided bone regeneration technique with BME-10X medical collagen membrane and Heal-all oral biofilm respectively. X-ray and clinical examination were taken at 1 and 3 months after implantation. The amount of new-formed bone tissue was evaluated when stage II operation was performed.
RESULTS AND CONCLUSION: In stage II operation, osseointegration was formed between implants and bone tissue in all 72 patients. The average rate of bone formation was 92% in the experimental group while 91% in the control group. All implants were successfully repaired with implant denture. Occlusal function was restored successfully with all 72 implants during the follow-up period of 3-24 months after restoration. As an alternative option of BME-10X medical collagen membrane, Heal-all oral biofilm can be used in guided bone formation clinically.

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