中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (8): 1488-1490.doi: 10.3969/j.issn.1673-8225.2010.08.038

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

聚丙烯酰胺水凝胶注射后伴发乳房恶性肿瘤：2例报道

王  慕1，王晓阳2，侯晓冬1，荣  蓉1，周志钢1，李  香3，欧阳雪3   

  1. 武警上海总队医院，1整形外科，  3病理科，上海市  201103， 2上海比华利医疗美容门诊，上海市  200002
  • 出版日期:2010-02-19 发布日期:2010-02-19
  • 通讯作者: 周志钢，副主任医师，武警上海总队医院整形外科，上海市 201103 zg918@yahoo.com.cn
  • 作者简介:王 慕★，女，1976年生，汉族，主治医师，2004年解放军第二军医大学毕业，硕士，主要从事整形、美容研究。 wm122588@hotmail.com

Breast malignant tumor following polyacrylamide hydrogel injection: Two cases report

Wang Mu1, Wang Xiao-yang2, Hou Xiao-dong1, Rong Rong1, Zhou Zhi-gang1, Li Xiang3, Ouyang Xue3   

  1. 1 Department of Plastic and Aesthetic Surgery, 3 Department of Pathology, Shanghai Chinese People’s Armed Police Force Hospital, Shanghai  201103, China; 2 Shanghai Beverly Hills Medical Cosmetic Clinic, Shanghai  200002, China
  • Online:2010-02-19 Published:2010-02-19
  • Contact: Zhou Zhi-gang, Associate chief physician, Department of Plastic and Aesthetic Surgery, Shanghai Chinese People's Armed Police Force Hospital, Shanghai 201103, China zg918@yahoo.com.cn
  • About author:Wang Mu★, Master, Department of Plastic and Aesthetic Surgery, Shanghai Chinese People's Armed Police Force Hospital, Shanghai 201103, China wm122588@hotmail.com

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摘要：

背景：聚丙烯酰胺水凝胶注射隆胸在中国一些医疗单位已经应用了近10年，因出现并发症而要求行注射物取出或同时进行再次隆胸的患者不在少数。在诊治过程中可能伴发乳房恶性肿瘤，临床上应给予足够的重视。
目的：回顾聚丙烯酰胺水凝胶注射填充物取出患者中确诊乳腺浸润性导管癌的2例个案，提高对于乳房恶性肿瘤检诊重要性的进一步认识。
方法：收集聚丙烯酰胺水凝胶隆乳术后发生并发症要求注射物取出的患者41例(共计82侧乳房)，其中2例伴发单侧乳房恶性肿瘤，术后病理均提示：乳腺浸润性导管癌；回顾分析病史特点、物理诊断、影像学诊断、病理检查等资料。
结果与结论：因聚丙烯酰胺水凝胶注射隆胸术后就诊的患者，应提高对于乳房恶性肿瘤检诊重要性的进一步认识；诊疗过程中强调对物诊及多种影像学检查结果做综合分析，手术过程中对可疑结节多点取材，取材过程中应注意“无瘤操作”手法，及时送冰冻病理检查，一旦确诊乳房恶性肿瘤，需及时按照乳房肿瘤诊疗规范来进行相关处理，以避免医源性操作失当导致的肿瘤漏诊、加速转移和播散。

关键词: 注射隆胸, 并发症, 乳房恶性肿瘤, 浸润性导管癌, 聚丙烯酰胺水凝胶, 生物医用水凝胶材料

Abstract:

BACKGROUND: Breast augmentation with polyacrylamide hydrogel injection has been used nearly for a decade in some Chinese medical therapy units. More patients need to be removing injections or a second augmentation due to complications. More attention should be paid for possibility of complications concomitant with breast malignant tumor.
OBJECTIVE: Two cases of breast invasive duct carcinoma diagnosed after removing injection were analyzed retrospectively in order to increase the importance of detection rate of breast malignant tumor.
METHODS: Two cases in all 41 assembled patients which were removed polyacrylamide hydrogel injections from 82 breasts were diagnosed with invasive carcinoma. The characteristics of medical history, physical diagnosis, image diagnosis and pathological examination were analyzed retrospectively.
RESULTS AND CONCLUSION: The detection rate of breast malignant tumor should arise more attention in patients requiring removal of polyacrylamide hydrogel injection. The following aspects should be emphasized such as the comprehensive analysis for the results of physical diagnosis and image diagnosis, tumor-free operation with more samples from suspicious nodules and frozen pathological examination. The principles of cancer surgery should be followed in pathological diagnosed cases in case of iatrogenic metastasis and spread of breast malignant tumor.

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