中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5419-5422.doi: 10.3969/j.issn.1673-8225.2010.29.025

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

输尿管支架的生物相容性及临床应用

贾书雷,于德凯,杨  东   

  1. 济源市中医院泌尿外科,河南省济源市  454650
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 作者简介:贾书雷,男,1963年生,河南省济源市人,汉族,主治医师,主要从事泌尿外科方面的研究。 shuleige@163.com

Biocompatibility and clinical application of ureteral stent

Jia Shu-lei, Yu De-kai, Yang Dong   

  1. Department of Urinary Surgery, Chinese Medicine Hospital of Jiyuan City, Jiyuan   454650, Henan Province, China
  • Online:2010-07-16 Published:2010-07-16
  • About author:Jia Shu-lei, Attending physician, Department of Urinary Surgery, Chinese Medicine Hospital of Jiyuan City, Jiyuan 454650, Henan Province, China shuleige@163.com

摘要:

目的:总结近年输尿管支架材料的生物相容性及临床应用情况。
方法:由作者应用计算机检索维普数据库中与输尿管支架材料有关的文章,检索时限1998-01/2010-04。检索关键词:输尿管;支架材料;双J管。纳入标准:①输尿管支架材料生物相容性有关的文章。②输尿管支架的应用效果以及出现的不良反应。排除标准:重复研究或较陈旧文献。根据纳入排除标准共保留相关文献28篇。
结果:目前应用于输尿管支架的生物材料,最常见的是人工合成多聚物,但并发症较多,生物相容性较差。金属输尿管支架具有价格较贵、置入后不易取出,容易出现支架移位等并发症。可降解材料支架能够有效的保持输尿管引流通畅,并发症发生率低,安全性好,生物相容性较好,目前该领域尚处在基础研究阶段。临床上应根据患者病情的选择合适的支架材料进行置入治疗。支架置入时操作应严格,出现并发症时进行积极对症治疗,可有效防治并发症。
结论:各种输尿管支架的生物相容性均有待提高;输尿管内支架操作简便,作用显著,患者耐受良好,但是必需了解及注意预防支架置入后可能发生的并发症。

关键词: 输尿管支架材料, 双J管, 生物相容性, 不良反应, 生物材料

Abstract:

OBJECTIVE: To summarize the biocompatibility and clinical applications of ureteral stent in recent years.
METHODS: A computer search was performed by the author in the VIP database to retrieve articles about ureteral stent materials. The search time limit was 1998-01/2010-04. Key words are ureter; stent material; double-J tube in Chinese. Inclusion criteria: ① articles related to ureteral stent biocompatibility; ② application of ureteral stent and the resulting side effects. Exclusion criteria: repeated studies or old literatures. According to the inclusion and exclusion criteria, 28 literatures were retained.
RESULTS: The most common biological material currently used in ureteral stents, is the synthetic polymer, but with more complications and poor biocompatibility. Metal ureteral stent is expensive and difficult to remove after implantation, prone to stent displacement. Biodegradable ureteral stent can effectively maintain the drainage patency, low complication rate, be safe and good biocompatible, it is still in the stage of basic research. Clinically, stent materials should be selected for the placement according to patients’ disease. The operation should be strict for stent implantation, symptomatic treatment should be given when complications occur, to prevent complications.
CONCLUSION: The biocompatibility of ureteral stents is needed to be improved; ureteral stent is simple and effective, the patient is well tolerated, but it is necessary to understand and prevent the stent complications after implantation.

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