中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (23): 4332-4335.doi: 10.3969/j.issn.1673-8225.2011.23.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

牙源干细胞参与组织再生修复的作用

李  颖1，谷子芽2   

  1. 1浙江省医学科学院生物工程所，浙江省杭州市  310012
    2浙江省杭州口腔医院，浙江省杭州市310012
  • 收稿日期:2010-11-24 修回日期:2011-02-24 出版日期:2011-06-04 发布日期:2011-06-04
  • 作者简介:李颖★，女，1983年生，浙江省湖州市人，汉族，2008年浙江大学毕业，硕士，研究实习员，主要从事干细胞的研究。 Liying19831121@yahoo.com.cn
  • 基金资助:

    浙江省医学科学院青年基金(A40918E)。

Effect of dental stem cells involved in tissue regeneration repair

Li Ying1, Gu Zi-ya2   

  1. 1Institute of Biological Engineering, Zhejiang Academy of Medical Sciences, Hangzhou  310012, Zhejiang Province, China
    2Hangzhou Stomatological Hospital, Hangzhou  310012, Zhejiang Province, China
  • Received:2010-11-24 Revised:2011-02-24 Online:2011-06-04 Published:2011-06-04
  • About author:Li Ying★, Master, Institute of Biological Engineering, Zhejiang Academy of Medical Sciences, Hangzhou 310012, Zhejiang Province, China Liying19831121@yahoo.com.cn
  • Supported by:

    Excellent Youth Foundation of Zhejiang Academy of Medical Sciences, No. A40918E*

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摘要：

背景：随着干细胞技术的不断发展，牙源性干细胞的研究也不断深入。它们是十分理想的种子细胞来源，在牙组织工程的应用上具有无可比拟的优势。
目的：综述牙源干细胞的相关研究进展。
方法：由第一作者检索PubMed数据库、Highwire数据库及中国知网(CNKI)数据库。英文检索词为“dental stem cells，tissue engineering, application”，中文检索词为“牙源干细胞，组织工程，应用”。初步检索文献量总计156篇，选择牙源性干细胞，包括牙髓干细胞和牙周膜干细胞等在组织工程中的基础研究及临床应用相关报道，排除陈旧及重复实验文章，最终纳入30篇符合标准的文献。
结果与结论：多种牙源干细胞，都具有较强自我更新能力和多向分化的能力，与目前研究较为深入的骨髓间充质干细胞有很大的相似性，因此在组织工程，尤其是牙组织工程上有良好的应用前景。目前虽然有关牙源干细胞在牙组织再生的应用上有一定报道，但研究不多，且仅处于动物模型阶段。相信随着科技进步，在不久的将来，各种牙源干细胞有望真正进入临床，为解决人类各种口腔疾病提供可能。

关键词: 牙源干细胞, 牙髓干细胞, 牙周膜干细胞, 组织工程, 临床应用

Abstract:

BACKGROUND: With the development of stem cell technology, researches on dental stem cells have also come into sight. Dental stem cells are ideal resources of seed cells, which have the incomparable advantages on the application of tooth tissue engineering.
OBJECTIVE: To summarize relative research progress on dental stem cells.
METHODS: PubMed database, Highwire database and CNKI database was retrieved by the first author, with the key words of “dental stem cells, tissue engineering, application” in English and Chinese, respectively. Totally 156 literatures were initially selected, from which studies about the application of dental stem cells, including dental pulp stem cells and periodontal ligament stem cells on tissue engineering, while outdated and duplicated literatures were excluded. Finally 30 literatures were included.
RESULTS AND CONCLUSION: Various dental stem cells have the capability of self-renew and multipotential differentiation. They share many similarities with bone marrow derived mesenchymal stem cells, which are better understood currently. Therefore, dental stem cells have a promised future in tissue engineering, especially dental tissue engineering. However, there are only a few reports about application of dental stem cells on tissue regeneration, and the studies only stuck at a stage of animal models. With the development of science and technology, various dental stem cells are hopefully coming into clinical application, providing possibility to cure oral diseases of human beings.

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