中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (33): 6223-6225.doi: 10.3969/j.issn.1673-8225.2010.33.035

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

角膜新生血管的发生与治疗

Wang Jun-hua, Gao Gui-ping   

  1. 南昌大学第一附属医院眼科，江西省南昌市 330006
  • 出版日期:2010-08-13 发布日期:2010-08-13
  • 通讯作者: 高桂平，副主任医师，南昌大学第一附属医院眼科，江西省南昌市 330006
  • 作者简介:王军花★，女，1984年生，江西省南丰县人，汉族，2008年成都中医药大学毕业，硕士，主要从事眼表角膜疾病方面的研究。 huahua2006525@163.com

Corneal neovascularization and treatment

王军花，高桂平   

  1. Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Gao Gui-ping, Associate chief physician, Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • About author:Wang Jun-hua★, Master, Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China huahua2006525@163.com

PDF

652

被引次数

9

摘要：

背景：角膜新生血管是国内较常见的致盲眼病之一，但至今尚无特效药物以及特效的治疗方法。
目的：全面了解角膜新生血管的发病机制，归纳各种针对角膜血管疾病的治疗方法。
方法：电子检索PubMed数据库和中国知识资源总库(CNKI)1989/2009收录的有关角膜新生血管的发病机制及治疗方法的随机对照或半随机对照实验，分析角膜新生发病因素和目前主要的治疗方法及效果。
结果与结论：共纳入27个研究，角膜新生血管能损伤患者视力，角膜水肿、血管因子、炎症反应、缺氧、角膜神经等均可能引起角膜新生血管的发生，阿瓦斯汀、脱氧核酶、小干扰RNA、光动力疗法、中药等对角膜新生血管的发生有一定的抑制作用，目前已处于临床或动物实验研究阶段。且随着技术的发展，针对角膜新生血管的治疗技术将更加安全有效。

关键词: 角膜新生血管, 阿瓦斯汀, 脱氧核酶, 小干扰RNA, 光动力疗法, 组织工程

Abstract:

BACKGROUND: Corneal neovascularization commonly lead to blind in China, however, which have not a patent medicine or treatment method.
OBJECTIVE: To overall understand the pathogenesis of corneal neovascularization, and to review the treatment methods for corneal vascular diseases.
METHODS: Databases of PubMed and CNKI were retrived by computer to search randomized controlled or semi-randomized controlled experiments concerning pathogenesis and treatment methods for corneal neovascularization.
RESULTS AND CONCLUSION: A total of 27 papers were included. Corneal neovascularisation, caused by corneal edema, vascular factors, inflammatory reaction, hypoxia, or corneal nerve damage, could damage visual acuity of patients. Therapies such as Avastin, Deoxyribozyme, small RNA interference, monoclonal antibody, photodynamic, and traditional Chinese Medicine have been systematic clinic or animal experiment to check their security and effectiveness. With the development of technology, corneal neovascularisation therapy would be safe and effective in future.

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