中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (21): 3943-3944.doi: 10.3969/j.issn.1673-8225.2010.21.034

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

淀粉作为药物载体的研究现状及应用

陈立新1，陈  茜2   

  1. 1辽宁省金秋医院，辽宁省沈阳市   110016；2中国药科大学生命学院，江苏省南京市  210009
  • 出版日期:2010-05-21 发布日期:2010-05-21
  • 作者简介:陈立新，女，1965年生，辽宁省沈阳市人，汉族，2004年吉林大学生物制药专业毕业，主管药师，主要从事临床药学研究。liledao@163.com

Research and application of starch as a drug carrier

Chen Li-xin1, Chen Qian2   

  1. 1 Liaoning Jin Qiu Hospital, Shenyang   110016, Liaoning Province, China; 2 College of Life Sciences, China Pharmaceutical University, Nanjing  210009, Jiangsu Province, China
  • Online:2010-05-21 Published:2010-05-21
  • About author:Chen Li-xin, Pharmacist-in-charge, Liaoning Jin Qiu Hospital, Shenyang 110016, Liaoning Province, China liledao@163.com

PDF

605

被引次数

20

摘要：

目的：综合分析淀粉作为药物载体的研究与应用进展。
方法：采用计算机检索1991-01/2009-12与药物载体及药物缓释制剂相关文章，排除重复研究或Meta分析类文章。以24篇文献为主重点讨论了淀粉作为药物载体的研究现状。
结果：作为一种新型的药物载体，淀粉作为一类生物可降解性高分子，基于它良好的生物相容性，在医药缓释助剂的开发和研制中，提高治疗效果也占有非常重要的地位。文章对淀粉类功能材料如淀粉基质片、微胶囊、微球及淀粉纳米粒的一般特点、合成方法、载药途径以及发展状况等作一综述介绍。
结论：目前，纳米粒子以其特有的优点引起了科研工作者的广泛关注。纳米粒可通过表面修饰或通过特殊材料的使用达到靶向目的，有利于难溶性药物的吸收和提高药物的生物利用度，稳定性好，尤其是可实现细胞内靶向的特点使其在肿瘤治疗领域有着广阔的应用前景。

关键词: 药物载体, 淀粉, 控制释放, 微胶囊, 微球, 纳米粒

Abstract:

OBJECTIVE: To comprehensively analyze the research and application progress of starch as a drug delivery carrier.
METHODS: A computer search was performed for articles published from January 1991 to December 2009. Articles related to the drug carrier and drug controlled release preparation were included, while duplicated articles or Meta analysis articles were excluded. Totally 24 articles mainly discussed the types and performance of tissue engineered blood vessel materials.
RESULTS: As a new drug carrier, starch can serve as a type of biodegradable polymers, based on its good biocompatibility, it plays a very important role in research and development of pharmaceutical controlled release additives, also in increasing treatment effect. Articles have introduced the general characteristics, synthetic methods, drug carrying approaches and development of starch functional materials such as starch matrix tablets, microcapsules, microspheres and starch nanoparticles.
CONCLUSION: At present, the nano-particle has attracted widespread concern from research workers due to its unique advantages. By surface modification or the use of special materials, nanoparticles could reach target, contributing to the absorption of insoluble drugs, and improving drug bioavailability and stability, in particular, the capacity of targeting into cells indicates a potential application in the field of tumor treatment.

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