中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (21): 3939-3942.doi: 10.3969/j.issn.1673-8225.2010.21.033

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

缓释、控释药用高分子材料的临床应用

曾春香，张斯汉   

  1. 深圳市龙岗区人民医院，广东省深圳市  518172
  • 出版日期:2010-05-21 发布日期:2010-05-21
  • 作者简介:曾春香，女，1977年生，广东省梅州市人，2000年广东药学院药学毕业，学士，主管药师，主要从事临床与药学方面的研究。 szlgyyj@sohu.com

Clinical application of sustained-release and controlled-release medical polymer materials

Zeng Chun-xiang, Zhang Si-han   

  1. People’s Hospital of Longgang District, Shenzhen   518172, Guangdong Province, China
  • Online:2010-05-21 Published:2010-05-21
  • About author:Zeng Chun-xiang, Pharmacist-in- charge, People’s Hospital of Longgang District, Shenzhen 518172, Guangdong Province, China szlgyyj@sohu.com

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1322

被引次数

43

摘要：

目的：分析缓释、控释药用高分子材料的特点，探讨其应用前景。
方法：以 “缓释药物，控释药物，高分子材料，药物载体，临床应用为中文关键词；以“controlled drug release，drug delivery，drug release material，polymer material，clinical application”为英文关键词，采用计算机检索2003-01/2010-03相关文章。纳入与有关缓释、控释药用高分子材料的临床应用的文章；排除重复研究或Meta分析类文章。以30篇文献为主重点进行了讨论缓释、控释药用高分子材料的种类及性能特点。
结果：近年来缓释、控释技术发展迅速，缓释、控释制剂的研究、开发和利用，充分满足了临床的需要，为广大患者防病治病提供了有力的保证。临床上适宜于制成缓释、控释制剂的药物范围广泛,各种类型的缓控释制剂，如骨架型缓释制剂、包衣缓释制剂、缓释胶囊、微囊缓释制剂、缓释膜剂、缓释栓剂等被广泛应用于临床。                                                                             
结论：在缓控释制剂中，高分子材料几乎成了药物在传递、渗透过程中的不可分割的组成部分。缓控释制剂的发展虽然与制药设备都在不断的更新，但是完全达到理想的应用标准还有一定的差距，研制使用新型材料和高质量的缓控释制剂还有待于临床工作者的进一步开发。

关键词: 缓释药物, 控释药物, 高分子材料, 药物载体, 临床应用

Abstract:

OBJECTIVE: To analyze the characteristics of sustained-release and controlled-release medical polymer materials, and to explore their application.
METHODS: Using “sustained-release drugs, controlled-release drugs, polymer material, drug delivery, clinical application” in Chinese and “controlled drug release, drug delivery, drug release material, polymer material, clinical application” in English as the keywords, a computer search was performed among articles published from January 2003 to March 2010. Articles related to clinical application of sustained-release and controlled-release pharmaceutical polymer materials were included; repeated study or Meta analysis articles were excluded. Thirty articles mainly discuss the type and performance characteristics of sustained- release and controlled-release medical polymer materials.
RESULTS: In recent years, sustained-release and controlled-release technologies are developing rapidly. Research, development and utilization of sustained-release and controlled-release formulations can greatly satisfy the clinical needs, and provide a strong guarantee for the prevention and treatment of many patients. There are a wide range of drugs suitable for the preparation of sustained-release and controlled-release pharmaceuticals, various types of sustained-release and controlled- release formulations, such as skeleton controlled-release formulations, coated controlled-release formulations, sustained-release capsules, microcapsule sustained-release formulations, sustained-release films, sustained-release suppositories have been widely used in the clinic.
CONCLUSION: The sustained-release and controlled-release formulations and the polymer materials have almost become an inalienable component of drug delivery and penetration process. Although the development of sustained-release and controlled- release formulations, as well as pharmaceutical equipment are constantly updated, they are not enough to achieve the desired application standards. Therefore, a new kind of materials with sustained-release and controlled-release characteristics should be developed.

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