A Meta-analysis of carotid intima-media thickness and subclinical hypothyroidism

doi:10.3969/j.issn.2095-4344.2015.02.028

Abstract

Abstract:

BACKGROUND: Recently, subclinical hypothyroidism has been associated with increased carotid intima-media thickness, but it is controversial.
OBJECTIVE: To assess whether carotid intima-media thickness in patients with subclinical hypothyroidism differs from that in euthyroid subjects.
METHODS: We searched published studies concerning the carotid intima-media thickness of patients with subclinical hypothyroidism in comparison with euthyroid subjects. Then, we evaluated each potential study for eligibility, assessed the methodological quality, and extracted the data for a Meta-analysis.
RESULTS: Eight observational studies with 3 602 cases met the eligibility criteria. In patients with subclinical hypothyroidism, the pooled estimate of the weighted mean difference (WMD) of increased carotid intima-media thickness was 0.056 [95% CI (0.020, 0.092)]. Sensitivity analysis using a pooled result of the seven higher-quality studies demonstrated higher carotid intima-media thickness level in patients with subclinical hypothyroidism than in euthyroid subjects [WMD=0.064, 95% CI (0.024, 0.105)]. In a subgroup analysis, subclinical hypothyroidism was even more significantly associated with the carotid intima-media thickness in patients with a mean thyrotropin level > 10.0 mU/L [WMD=0.082, 95% CI (0.049, 0.116)]. Subclinical hypothyroidism was also associated with a significant increase in systolic blood pressure, triglyceride levels, total cholesterol levels, low-density lipoprotein levels and with a decrease in fasting plasma glucose. This meta-analysis indicates that subclinical hypothyroidism
is associated with an increased carotid carotid intima-media thickness, which may be due to elevated thyrotropin, dyslipidemia and hypertension. Despite the obvious individual differences, a prospective large-sample study is necessary to further assess the conclusions of this observation.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Hypothyroidism, Thyrotropin, Hypertension

CLC Number:

R318

Zhang Zhao-yun, Abulikemu Tuerdi. A Meta-analysis of carotid intima-media thickness and subclinical hypothyroidism[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(2): 310-315.

Figures/Tables 3

References

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