Autologous peripheral blood stem cell transplantation combined with core decompression for the treatment of avacscular necrosis of the femoral head in patients with systemic lupus erythematosus

doi:10.3969/j.issn.2095-4344.2014.50.024

Abstract

Abstract:

BACKGROUND: There are less studies addressing whether the clinical outcomes about the autologous peripheral blood stem cell transplantation combined with core decompression for the treatment of systemic lupus erythematosus with avascular necrosis of the femoral head are different from the simple core decompression.
OBJECTIVE: To observe the clinical outcomes of autologous peripheral blood stem cell transplantation combined with core decompression for the treatment of systemic lupus erythematosus with avascular necrosis of the femoral head.
METHODS: Systemic lupus erythematosus patients with avascular necrosis of the femoral head admitted at the Affiliated Longyan First Hospital of Fujian Medical University from October 2004 to October 2014 were enrolled and divided into transplantation group (n=22) and control group (n=26) according to different therapies. Patients in the two groups were subjected to autologous peripheral blood stem cell transplantation combined with core decompression and simple core decompression, respectively.
RESULTS AND CONCLUSION: In the transplantation group, the levels of white blood cells, C-reactive protein, C3 and C4 as well as erythrocyte sedimentation rate were significantly increased at 1 week after treatment, while the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, serum creatinine, uric acid, IgM, IgG, IgA, ds-DNA levels still maintained in the normal range. Compared with the control group, the Harris scores were increased (6, 12, 24 months after treatment) and visual analog scale scores were reduced (12, 24 months after treatment) in the transplantation group after treatment. Moreover, the necrosis area of the femoral head shown on the T1W1 of MRI in the transplantation was also smaller than that in the control group. These findings indicate that the autologous peripheral blood stem cell transplantation combined with core decompression for the treatment of systemic lupus erythematosus with avascular necrosis of the femoral head can remarkably relieve the pain, promote the blood supply in the necrosis area, ameliorate the hip joint function, and prevent the collapse of the femoral head, which is an easy and safe treatment preserving the femoral head in systemic lupus erythematosus patients with avascular necrosis of the femoral head in early and middle stages.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: stem cells, peripheral blood, lupus erythematosus, systemic, avascular necrosis of the femoral head, femur head

CLC Number:

R394.2

Yu Lian, Chen Long-tian, Lai Qin, Qiu Yong-long, Huang Jian-qing, Lin Qi, Wu Fu-chun . Autologous peripheral blood stem cell transplantation combined with core decompression for the treatment of avacscular necrosis of the femoral head in patients with systemic lupus erythematosus[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(50): 8174-8179.

Figures/Tables 3

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