Allogenic acellular extracellular matrix repairs high anal fistula

doi:10.3969/j.issn.2095-4344.2014.34.015

Abstract

Abstract:

BACKGROUND: Treatment methods for high anal fistula include fistula removal, incision and thread drawing, selective mucosal flap displacement, fibrin glue closure, fistula liagtion between sphincter, most of which show many advantages, including long-term healing, a low success rate, high recurrence rate, and high postoperative complication rate.

OBJECTIVE: To observe the clinical effect of acellular extracellular matrix in the treatment of high anal fistula, and to explore a minimally invasive treatment for high anal fistula.

METHODS: Totally 100 cases of high anal fistula were randomly divided into treatment group and control group, 50 cases in each group. Treatment group were treated with allogenic acellular extracellular matrix, and control group were treated with traditional low incision with high thread-drawing. Then, we observed and compared the operation time, bleeding volume, postoperative pain score (visual analog scale score), postoperative pain duration, anal incontinence severity score (Wexner score), wound healing time, one-stage success rate, cure rate, recurrence rate.

RESULTS AND CONCLUSION: Compared with the control group, the treatment group showed lower scores in the operation time, bleeding volume, wound healing time, visual analog scale score, postoperative pain duration, and anal incontinence severity score (P < 0.05), but higher scores in one-stage success rate and cure rate (P < 0.05). There was no difference in the recurrence rate between the two groups. These findings indicate that the allogenic acellular extracellular matrix for treatment of high anal fistula exhibits small trauma, quick recovery, short course of treatment, high cure rate and has no damage to the anal function and appearance.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: rectal fistula, recurrence, comparative study

CLC Number:

R318

Wang Jian-cheng, Wang Wei, Zhang Ke, Zou Shi-zhen . Allogenic acellular extracellular matrix repairs high anal fistula [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(34): 5497-5502.

Figures/Tables 1

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