Abstract:

BACKGROUND: Serum tumor necrosis factor α and interleukin-1β as an inflammatory mediator is related to the condition of osteoarthritis. However, the reports on the treatment of osteoarthritis by bone marrow mesenchymal stem cells are rare.
OBJECTIVE: To observe the T2 value, the serum tumor necrosis factor α and interleukin-1β levels in the treatment of early osteoarthritis in rabbits by bone marrow mesenchymal stem cells transplantation.
METHODS: Thirty-six New Zealand white rabbits were randomly and equally divided into control group, model group and treatment group. Rabbits in the model group were only used to establish the osteoarthritis model; left knee joint cavity of rabbits in the treatment group was injected with bone marrow mesenchymal stem cells at 4 weeks after modeling; knee joint cavity of rabbits in the control group was injected with normal saline in the same dose. Left knee joint magnetic resonance imaging and the detection of serum tumor necrosis factor α and interleukin-1β levels were performed at 2 weeks, 1, 2 and 3 months after treatment.
RESULTS AND CONCLUSION: Compared with the meodel group, the T2 value reduced, without arthroedema, and the serum tumor necrosis factor α and interleukin-1β levels were decreased in the treatment group. The T2 value was positive correlated with serum tumor necrosis factor α and interleukin-1β levels. MRI can reflect the early biologically change of articular cartilage, and it can be used to evaluate the curative effect in the early stages of osteoarthritis. Bone marrow mesenchymal stem cells can differentiate into chondrocytes in articular cavity and is effective for early osteoarthritis in rabbits.