Result analysis of four human leukocyte antigen rare alleles

doi:10.3969/j.issn.2095-4344.2013.44.025

Abstract

Abstract:

BACKGROUND: Many articles concerned novel alleles reported in China and outside China, but some alleles were detected lately. After that, these alleles were tested again. Because frequencies of these alleles are very low, few relevant articles are reported, so these alleles are ignored easily.
OBJECTIVE: To test and identify four human leukocyte antigen rare alleles that patients and donors carries.
METHODS: Genomic DNA was extracted automatically from blood samples using quick DNA purified kit, typed by human leukocyte antigen locus commercial sequence-based typing kits and confirmed by sequence-specific primers high-resolution kits.
RESULTS AND CONCLUSION: Four detected rare alleles are B*27:15, B*51:39, C*07:66 and C*08:22. The four above-mentioned human leukocyte antigen rare alleles defined by National Marrow Donor Program are not rare in China. The facts prove that C*08:22 which was defined a rare allele by National Marrow Donor Program before is a common allele in Chinese Han nationality.

Key words: HLA antigens, alleles, bone marrow, organ transplantation, cell transplantation

CLC Number:

R318

Wang Da-ming, He Liu-mei, Zou Hong-yan, Gao Su-qing. Result analysis of four human leukocyte antigen rare alleles[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(44): 7809-7814.

Figures/Tables 4

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