Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (14): 2583-2586.doi: 10.3969/j.issn.1673-8225.2011.14.024

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Adipogenic differentiation of bone marrow stromal stem cells intervened with serum containing different concentration Epimedium 

Liu Hong-jiang1, Liu Hai-quan1, Qin Jia-jia2   

  1. 1Orthopedic Hospital, Guangzhou University of Chinese Medicine, Guangzhou  510405, Guangdong Province, China
    2Jinan University, Guangzhou  510632, Guangdong Province, China
  • Received:2011-01-04 Revised:2011-03-05 Online:2011-04-02 Published:2013-11-02
  • Contact: Liu Hai-quan, Associate investigator, Orthopedic Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • About author:Liu Hong-jiang★, Master, Attending physician, Orthopedic Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China gdgzhlhj@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30901915*; China Postdoctor Science Foundation, No. 20080440744*

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Abstract:

BACKGROUND: How to inhibit adipogenic differentiation of bone marrow stromal stem cells (BMSCs) and promote the osteogenic differentiation of BMSCs is a new approach to prevention and treatment of osteoporosis.
OBJECTIVE: To investigate the effect of serum containing different concentration Epimedium on adipogenic differentiation of BMSCs in rats with osteoporosis.
METHODS: Three of 15 SPF-class SD female rats were used to isolate and culture BMSCs. The remaining 12 rats were divided into control group, high dose herb group, medium dose herb group, low dose herb group. Adipogenic differentiation was observed after 7 day’s intervention.
RESULTS AND CONCLUSION: Medium and low dose herb groups played the effects on suppressing adipogenic differentiation of BMSCs (P < 0.01, 0.05). There was no significant difference among each herb groups (P > 0.05). The medium dose herb was the best in different concentration dose herb on inhibiting adipogenic differentiation of BMSCs.

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