Abstract:

BACKGROUND: Platelet transfusions were shown to reduce mortality from hemorrhage in patients with acute leukemia in the 1950s, and the use of the therapy has steadily grown since then. The procedure has become an essential part of hematopoietic stem cell transplantation (HSCT) treatment. However, there are rare studies about the current transfusion practices.
OBJECTIVE: To retrospectively analyze the effects of platelet transfusion in 52 patients undergoing HSCT.
METHODS: Prophylactic versus therapeutic platelet transfusion was grouped according to platelet counts and bleeding manifestation. The factors potentially influencing platelet transfusion efficacy after HSCT were evaluated.
RESULTS AND CONCLUSION: The effective rates of prophylactic and therapeutic platelet transfusion groups were 63.6% and 55.6%, respectively. The effective rates and mean platelet increment in patients undergoing HSCT were 60.9% and 26.8×10⁹/L. Meanwhile, the efficacy of prophylactic and therapeutic platelet transfusion in patients who received autologous transplants was similar in the group of allogeneic HSCT. Coagulation disorder as a independent factor identified by binary Logistic Regression showed influencing the efficacy of platelet transfusion．The platelet transfusion is an effectively therapeutic method for thrombocytopenic patients undergoing HSCT. The effect of prophylactic platelet transfusion is better than therapeutic platelet transfusion in these patients. The difference was not seen between the groups of autologous and allogeneic transplants. The curative effect of platelet transfusion can be influenced by coagulation disorder.