Bone marrow mesenchymal stem cell transplantation for experimental spinal cord injury: transplantation routes and combination modes

doi:10.3969/j.issn.2095-4344.2012.49.026

Abstract

Abstract:

BACKGROUND: Different ways of bone marrow mesenchymal stem cells transplantation produce different degrees of functional recovery of spinal cord injury. Transplantation of simple bone marrow mesenchymal stem cells yields unsatisfactory efficacy in recovery of spinal cord injury.
OBJECTIVE: To review the transplantation routes and combination modes regarding bone marrow mesenchymal stem cells transplantation for the treatment of experimental spinal cord injury.
METHODS: A computer-based online retrieval was performed by the first author in CNKI and PubMed databases to search papers published during 1995-01/2011-12 with the key words “ bone marrow mesenchymal stem cells, cellular transplant, spinal cord injury, explanation channel, modality alliance” in Chinese and English. Forty-seven papers were included in the final analysis.
RESULTS AND CONCLUSION: There are many transplantation routes used for cell transplantation for the treatment of spinal cord injury, including in situ transplantation, transplantation via the cerebrospinal fluid, intravenous transplantation, transplantation via the abdominal cavity and tissue engineering scaffold. The tissue engineering scaffold method produces optimal efficacy, followed by in situ transplantation and transplantation via the cerebrospinal fluid, and the efficacy of intravenous transplantation and transplantation via the abdominal cavity is poor. Bone marrow mesenchymal stem cells combined with other ways of transplantation in the treatment of spinal cord injury has been widely recognized by scholars, but the treatment schemes of spinal cord injury targeting different injury times, patterns and extents need to be further standardized and assessed.

CLC Number:

R318

Zhang Da, Tu Guan-jun. Bone marrow mesenchymal stem cell transplantation for experimental spinal cord injury: transplantation routes and combination modes[J]. Chinese Journal of Tissue Engineering Research, 2012, 16(49): 9265-9270.

Figures/Tables 1

References

[1] Fukuda S, Nakamura T, Kishigami Y,et al. New canine spinal cord injury model free from laminectomy. Brain Res Brain Res Protoc. 2005;14(3):171-180.

[2] Kang SK, Shin MJ, Jung JS,et al. Autologous adipose tissue-derived stromal cells for treatment of spinal cord injury.Stem Cells Dev. 2006;15(4):583-594.

[3] Lepore AC, Bakshi A, Swanger SA, et al. Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res. 2005; 1045(1-2):206-216.

[4] Lim JH, Byeon YE, Ryu HH,et al. Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. J Vet Sci. 2007;8(3):275-282.

[5] Nishio Y, Koda M, Kamada T, et al. The use of hemopoietic stem cells derived from human umbilical cord blood to promote restoration of spinal cord tissue and recovery of hindlimb function in adult rats. J Neurosurg Spine. 2006;5(5): 424-433.

[6] Fehlings MG, Sekhon LH. Acute interventions in spinal cord injury: what do we know, what should we do. Clin Neurosurg. 2001;48:226-242.

[7] Parr AM, Kulbatski I, Zahir T,et al. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience. 2008;155(3):760-770.

[8] Nandoe Tewarie RD, Hurtado A, Levi AD, et al. Bone marrow stromal cells for repair of the spinal cord: towards clinical application. Cell Transplant. 2006;15(7):563-577.

[9] Zhao ZM, Li HJ, Liu HY,et al. Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant. 2004;13(2):113-122.

[10] Colter DC, Class R, DiGirolamo CM,et al. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci U S A. 2000;97(7): 3213-3218.

[11] Hofstetter CP, Schwarz EJ, Hess D,et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A. 2002;99(4):2199-2204.

[12] Le Blanc K, Tammik C, Rosendahl K, et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol. 2003;31(10):890-896.

[13] Ankeny DP, McTigue DM, Jakeman LB. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp Neurol. 2004;190(1):17-31.

[14] Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine (Phila Pa 1976). 2004;29(18):1971-1979.

[15] Zhao LX, Zhang J, Cao F,et al. Modification of the brain-derived neurotrophic factor gene: a portal to transform mesenchymal stem cells into advantageous engineering cells for neuroregeneration and neuroprotection. Exp Neurol. 2004; 190(2):396-406.

[16] Vaquero J, Zurita M, Oya S,et al. Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration. Neurosci Lett. 2006;398(1-2):129-134.

[17] Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine (Phila Pa 1976). 2004;29(18):1971-1979.

[18] McKenzie AL, Hall JJ, Aihara N,et al. Immunolocalization of endothelin in the traumatized spinal cord: relationship to blood-spinal cord barrier breakdown. J Neurotrauma. 1995; 12(3):257-268.

[19] Takeuchi H, Natsume A, Wakabayashi T,et al. Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner. Neurosci Lett. 2007;426(2):69-74.

[20] Keirstead HS, Nistor G, Bernal G,et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 2005;25(19):4694-4705.

[21] Okano H, Ogawa Y, Nakamura M,et al. Transplantation of neural stem cells into the spinal cord after injury. Semin Cell Dev Biol. 2003;14(3):191-198.

[22] Maikos JT, Shreiber DI. Immediate damage to the blood-spinal cord barrier due to mechanical trauma. J Neurotrauma. 2007;24(3):492-507.

[23] Khalatbary AR, Tiraihi T. A comparative study of therapeutic benefits of intraspinal and intravenous bone marrow stromal cell administration to spinal cord injuries. Iran Biomed J. 2009; 13(1):43-48.

[24] 景文莉,闫凤霞,左彦珍.骨髓间充质干细胞不同移植途径治疗大鼠脊髓损伤的比较[J].中国组织工程研究与临床康复,2008, 12(51): 10045-10049.

[25] Takeuchi H, Natsume A, Wakabayashi T,et al. Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner. Neurosci Lett. 2007;426(2):69-74.

[26] 许祖远,方煌,罗永湘,等.神经干细胞静脉移植治疗脊髓损伤的实验研究[J]. 中国矫形外科杂志,2007,15(6):459-462.

[27] 冯大雄,钟德君,宋跃明.静脉移植骨髓间充质干细胞在大鼠损伤脊髓中的存活与分化[J].中国脊柱脊髓杂志,2006,16(7):527-531.

[28] Fan L, DU F, Cheng BC,et al. Migration and distribution of bone marrow stromal cells in injured spinal cord with different transplantation techniques. Chin J Traumatol. 2008;11(2):94-97.

[29] Ohta M, Suzuki Y, Noda T,et al. Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Exp Neurol. 2004;187(2):266-278.

[30] Bakshi A, Barshinger AL, Swanger SA,et al. Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation. J Neurotrauma. 2006;23(1):55-65.

[31] 李经伦,冯善伟,柳太云,等.骨髓基质干细胞在肌营养不良模型鼠中的分布及移植途径对分布的影响[J].中华神经科杂志,2006, 39(1):32-35.

[32] Kamada T, Koda M, Dezawa M,et al. Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J Neuropathol Exp Neurol. 2005;64(1):37-45.

[33] Marquina M, España A, Fernández-Galar M,et al. The role of nitric oxide synthases in pemphigus vulgaris in a mouse model. Br J Dermatol. 2008;159(1):68-76.

[34] Yang JY, Kim HS, Lee JK. Changes in nitric oxide synthase expression in young and adult rats after spinal cord injury. Spinal Cord. 2007;45(11):731-738.

[35] 赵廷宝,卢兆桐,赵凌云,等.骨髓间充质干细胞与嗅鞘细胞联合移植治疗脊髓损伤的早期观察[J].中国矫形外科杂志,2006,14(5): 346-348.

[36] Wewetzer K, Verdú E, Angelov DN,et al. Olfactory ensheathing glia and Schwann cells: two of a kind. Cell Tissue Res. 2002;309(3):337-345.

[37] Serruys PW, Regar E, Carter AJ. Rapamycin eluting stent: the onset of a new era in interventional cardiology. Heart. 2002; 87(4):305-307.

[38] Casha S, Yu WR, Fehlings MG. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience. 2001;103(1):203-218.

[39] Ricci S, Celani MG, Cantisani AT, et al. Piracetam for acute ischaemic stroke. Stroke. 2006; 37: 2191-2192.

[40] 贾宏伟,李艳英.骨髓间充质干细胞移植联合吡拉西坦修复大鼠脊髓损伤[J].中国组织工程研究与临床康复,2011,15(10):1783- 1788.

[41] 吕华兵,牛伟,卜志勇,等.红花黄素对骨髓间充质干细胞移植修复大鼠脊髓损伤的影响[J].湖北医药学院学报,2011,30(3):243-247.

[42] Tian J, Li G, Liu Z,et al. Hydroxysafflor yellow A inhibits rat brain mitochondrial permeability transition pores by a free radical scavenging action. Pharmacology. 2008;82(2):121-126.

[43] 卜志勇,李安军,施永彦.红花黄素对大鼠脊髓损伤局部SOD 、MDA和细胞凋亡的影响[J].湖北医药学院学报,2011,30(1) : 23-25.

[44] Karimi-Abdolrezaee S, Eftekharpour E, Wang J,et al. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury.J Neurosci. 2006;26(13):3377-3789.

[45] 刘海,王忠诚,安沂华,等.高压氧对大鼠脊髓损伤后内源性神经干细胞的诱导作用[J].中国康复理论与实践,2006,12(5):369-371.

[46] 裴少保,方健,王海峰,等.骨髓间充质干细胞移植联合高压氧治疗兔脊髓冲击伤[J].安徽医科大学学报,2011,46(9):870-874.

[47] 范东艳,王苹,刘然,等.骨髓间充质干细胞移植和直流电刺激对大鼠脊髓损伤的修复作用[J].中国生物制品学杂志,2011,24(9): 1028-1032.