Application of bone marrow mesenchymal stem cells in the treatment of bone defects

doi:10.3969/j.issn.2095-4344.2012.49.027

Abstract

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells have multilineage differentiation potential, which can be induced to differentiate into osteoblasts and chondrocytes under special conditions in vitro or in vivo. They are widely used for bone tissue engineering.
OBJECTIVE: To review the basic research and clinical application of bone marrow mesenchymal stem cells for repair of bone defects.
METHODS: The CNKI database and PubMed database (1999-01/2012-01) were used to search the related articles about the application of bone marrow mesenchymal stem cells for repair of bone defects. The key words are “bone marrow mesenchymal stem cells, bone defect”. Articles concerning bone marrow mesenchymal stem cells for the treatment of bone defects were included. For the articles that published recently or in the high-impact journals were preferred, and articles with repetitive contents were ruled out. Then 30 articles were suitable for further analysis.
RESULTS AND CONCLUSION: Bone marrow mesechymal stem cells can be easily isolated from bone marrow. Bone marrow mesenchymal stem cells can be used to repair bone defects effectively because of their ability to differentiate into osteoblasts, especially with the development of biological scaffold materials and gene engineering technology.

CLC Number:

R318

Lin Zhao-wei, Li Qi. Application of bone marrow mesenchymal stem cells in the treatment of bone defects [J]. Chinese Journal of Tissue Engineering Research, 2012, 16(49): 9271-9275.

Figures/Tables 1

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