Chinese Journal of Tissue Engineering Research ›› 2026, Vol. 30 ›› Issue (28): 7456-7464.doi: 10.12307/2026.650

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Research context and trend of TANK binding kinase 1 in autoimmunity and tumor prevention and treatment

Xu Canli, He Wenxing, Wang Yuping, Ba Yinying, Chi Li, Wang Wenjuan, Wang Jiajia   

  1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Received:2025-06-30 Revised:2025-11-12 Online:2026-10-08 Published:2026-02-26
  • Contact: Wang Jiajia, PhD, Associate professor, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • About author:Xu Canli, MS candidate, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Supported by:
    National Natural Science Foundation of China, No. 82104765 (to WJJ); the First Batch of Beijing Traditional Chinese Medicine Flame Inheritance New 3+3 Project (Cultivation Category) - Feng Jianchun “Sanming” Inheritance Workshop, No. 2023-SZ-F-16 (to YX and WJJ)

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Abstract: BACKGROUND: The research results on TANK binding kinase 1, a bi-directional tumor regulator, have been increasing yearly, but there is no bibliometric literature to analyze the information in the literature related to TANK binding kinase 1.
OBJECTIVE: To explore the research status, hot spots, and trends of TANK binding kinase 1 based on bibliometric analysis. 
METHODS: We collected literature related to TANK binding kinase 1 in the last 10 years based on the SCIE database in the Web of Science Core Collection. The data were imported into CiteSpace 6.3.R1 and analyzed bibliometrically and visually with five options: country, author, institution, reference, and keyword. In addition, Origin 2021 was used to plot the relevant statistical graphs. 
RESULTS AND CONCLUSION: There was an upward trend in the number of publications and co-citations involved in TANK binding kinase 1 research. Dan-Dan Chen, Jian-Fang Gui, Qiwei Qin, and Shun Li were the four authors with the highest number of publications (n=11), while the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Zhejiang University, Chinese Academy of Agricultural Sciences, and Wuhan University had a larger number of publications (> 50). The research hot spots of TANK binding kinase 1 in the last decade mainly focus on innate immunity, the cyclic gmp-amp synthase-stimulator of interferon genes pathway, nuclear factor-κB, inflammation, optineurin, expression, cancer, etc. In recent years, academics from various countries have conducted sustained and in-depth research in related fields. TANK binding kinase 1 shows great potential for research in the autoimmune system, signaling pathways, gene expression, tumor control, and so on. But academic cooperation between academics and between institutions is not strong. In the future, cooperation and communication should be strengthened to grasp the research hot spots and trends of TANK binding kinase 1, to expand its research range in disease areas, and to provide more evidence for further elucidating the pharmacodynamic mechanisms and pathological changes of diseases.


Key words: TANK binding kinase 1 (TBK1), nuclear factor-κB-activated kinase, CiteSpace, Web of Science, bibliometrics, visualization, co-citation, research hotspot, frontier

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