High mobility group box 1 protein level in peri-implant crevicular fluid

doi:10.3969/j.issn.2095-4344.2013.03.010

Abstract

Abstract:

BACKGROUND: Recent studies have found that high mobility group box 1 protein (HMGB-1) as an important inflammatory factor plays a significant role in various inflammations.

OBJECTIVE: To determine the HMGB-1 level in the peri-implant gingival crevicular fluid and to investiage the correlation of HMGB-1 and peri-implant mucositis.

METHODS: Patients with healthy implant (n=39), with mild peri-implant mucositis (n=24) and moderate peri-implant mucositis (n=16) were enrolled. The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were detected. Clinical parameters were measured to investigate their relationships, including gingival index, mobility, plaque index, probing depth.

RESULTS AND CONCLUSION: The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were significantly higher in the patients with mild peri-implant mucositis than in the healthy implant patients (P < 0.01), but lower than the moderate peri-implant mucositis patients (P < 0.01). Gingival crevicular fluid volume was positively correlated with gingival index and plaque index (P < 0.01). The total amount of HMGB-1 was positively correlated with gingival index and probing depth (P < 0.01). No significant difference was found between probing depth and mobility and the level and total amount of HMGB-1. This investigation show that HMGB-1 level in the gingival crevicular fluid may be as a diagnostic marker for peri-implant mucositis.

Key words: biomaterials, tissue-engineered oral materials, high mobility group box 1 protein, peri-implant mucositis, clinical parameters, correlativity

CLC Number:

R318

Liu Jin-pan, Wang Ming-guo, Li Jing, Yang Shi-mao. High mobility group box 1 protein level in peri-implant crevicular fluid[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(3): 440-444.

Figures/Tables 3

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