Chinese Journal of Tissue Engineering Research ›› 2023, Vol. 27 ›› Issue (5): 813-820.doi: 10.12307/2023.069
Wang Xiaoge1, 2, Liu Jiwen3, Yang Shuai1, 2, Bao Jinyu1, Li Cui1, 2, 4
Received:
2022-01-26
Accepted:
2022-04-24
Online:
2023-02-18
Published:
2022-07-25
Contact:
Li Cui, Ph D, Lecturer, School of Physical Education (Main Campus), Zhengzhou University, Zhengzhou 450001, Henan Province, China; Institute of Neuroscience, Zhengzhou University, Zhengzhou 450001, Henan Province, China; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China
About author:
Wang Xiaoge, Master candidate, School of Physical Education (Main Campus), Zhengzhou University, Zhengzhou 450001, Henan Province, China
Supported by:
CLC Number:
Wang Xiaoge, Liu Jiwen, Yang Shuai, Bao Jinyu, Li Cui. Effects of exercise on depression-like behaviors in chronic unpredictable mild stress rodent models: a systematic review and Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(5): 813-820.
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2.4 Meta分析结果 2.4.1 运动对强迫游泳行为学影响的Meta分析结果 观察运动对强迫游泳行为学结果的影响,共纳入15篇文献[16-18,20-26,30-31,34,36-37],其中2篇文献包含2种运动方案[16,31],共17个研究。Meta分析结果显示,此17个研究存在较大的异质性,采用随机效应模型,合并效应量[SMD=-3.93,95%CI:(-4.88,-2.98),P < 0.000 01],见图4,表明运动干预可以改善CUMS抑郁模型鼠强迫游泳测试潜伏期。为了探讨异质性来源,对干预阶段、运动时间、运动方式和造模时间进行回归分析,见表3,探索可能的异质性来源。回归分析结果显示干预阶段、运动时间,运动方式和造模时间对研究间的异质性均没有显著影响。"
根据运动方式不同对悬尾测试行为学进行亚组分析,结果显示:无论是跑台、游泳还是自主转轮,运动组悬尾测试的潜伏期都显著低于对照组,见图6。对运动方式的亚组分析显示,跑台运动使悬尾测试潜伏期显著降低,与对照组比较有显著性意义[SMD=-7.46,95%CI:(-8.82,-6.10),P < 0.000 01],组内异质性检验I2=22%,异质性风险较低;游泳运动使悬尾测试潜伏期显著降低,差异具有统计学意义[SMD=-2.84,95%CI:(-3.41,-2.27),P < 0.000 01],组内异质性检验I2=75%,异质性风险较高;自主转轮运动使悬尾测试潜伏期显著降低,亦具有显著性差异[SMD=-4.39,95%CI:(-5.49,-3.28),P < 0.000 01],组内异质性检验I2=0%,无异质性风险。 "
2.4.3 运动对糖水偏好测试行为学影响的Meta分析结果 观察运动对糖水偏好测试行为学结果的影响共纳入17篇文献[17-20,22-23,27-30,32-38],其中2篇文献包含2种运动方案[27,33],共19个研究。Meta分析结果显示,此19个研究存在较大的异质性,采用随机效应模型,合并效应量[SMD=2.37,95%CI:(1.62,3.11),P < 0.000 01],表明运动干预可以改善CUMS抑郁模型鼠糖水偏好测试行为学的结果,见图7。鉴于运动对糖水测试行为学结果的研究间存在较大的异质性,根据纳入文献基本情况推测可能与造模时间、干预阶段、运动方式及运动时间等因素有关。为此,文章将上述因素作为协变量进行Meta 回归分析,探索可能的异质性来源。结果显示,造模时间、干预阶段、运动方式及运动时间对研究间的异质性无显著影响,见表5。"
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