Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (29): 4735-4741.doi: 10.12307/2022.836
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Xia Haisha1, Li Yuxi2, Liu Xiaobo1, Fan Jin1, Zhang Jiaming1, Gou Xinyun1, Li Juan1, Zheng Zhong3, Jin Rongjiang1
Received:
2021-11-11
Accepted:
2021-12-04
Online:
2022-10-18
Published:
2022-03-28
Contact:
Jin Rongjiang, MD, Professor, Doctoral supervisor, School of Health Cultivation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
About author:
Xia Haisha, Master candidate, School of Health Cultivation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
Supported by:
CLC Number:
Xia Haisha, Li Yuxi, Liu Xiaobo, Fan Jin, Zhang Jiaming, Gou Xinyun, Li Juan, Zheng Zhong, Jin Rongjiang. Gaze characteristics of emotional faces in depressed patients: a Meta-analysis based on eye movement studies[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(29): 4735-4741.
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2.3 Meta分析结果 2.3.1 各组注视时间的差异 (1)正性情绪图片:共纳入7项研究[18,20-22,24-25,28]。由于研究间异质性较大(I2=93%),故采用随机效应模型进行Meta分析,结果显示,病例组比对照组对正性情绪图片注视时间更短(SMD=-1.00,95%CI:-1.88至-0.12,P=0.03)。多次反复查验数据后,异质性来源仍较难解释,考虑为在研究对象的确定、无关变量的控制及研究工具的选择和使用上存在较大异质性,但大多数健康受试者均表现出明显的正性刺激偏向,不影响总体判断。 (2)中性情绪图片:共纳入9项研究[17-22,24-25,28],包括180例患者和209例对照。由于研究间异质性较大(I2=81%),故采用随机效应模型进行Meta分析,结果显示,病例组和对照组对中性情绪图片的注视时间的差异无显著性意义(SMD=-0.45,95%CI:-0.95-0.04,P=0.07),见图3A。排除Sears等[28]的研究后异质性明显降低(I2=45%),提示其为异质性来源。对其他研究汇总,因部分亚组内具有统计学异质性,故采用随机效应模型进行Meta分析,结果仍然显示差异无有显著性意义(SMD=-0.17,95%CI:-0.48-0.14,P=0.28),见图3B。"
(3)负性情绪图片:共纳入9项研究[17-22,24-25,28],包括180例患者和209例对照。由于研究间有异质性(I2=57%),故采用随机效应模型进行Meta分析,结果显示,病例组比对照组对负性情绪图片注视时间更长(SMD=0.89,95%CI:0.55-1.23,P < 0.000 01),见图3A。排除NEWMAN等[25]的研究后,研究异质性显著降低(I2=28%),提示其为异质性来源。对其他研究汇总,因部分亚组内具有统计学异质性,故采用随机效应模型进行Meta分析,结果仍然显示病例组比对照组对负性情绪图片注视时间更长(SMD=0.77,95%CI:0.50-1.04,P < 0.000 01),见图3B。 2.3.2 首视时间 (1)正性情绪图片:共纳入4项研究[20-21,23,26]。由于研究间异质性较大(I2=80%),故采用随机效应模型进行Meta分析,结果显示,病例组和对照组首视时间的差异无显著性意义(SMD=0.12,95%CI:-0.57-0.81,P=0.73),见图4A。排除LANZA等[23]及NOIRET等[26]的研究后异质性消失(I2=0%),提示其为异质性来源。对其他研究汇总并采用固定效应模型进行Meta分析,结果仍然显示差异无显著性意义(SMD=0.18,95%CI:-0.25-0.61,P=0.42),见图4B。"
(2)中性情绪图片:共纳入6项研究[17,20-21,23,26-27]。研究间异质性较小(I2=7%),但因部分亚组内具有统计学异质性,故采用随机效应模型进行Meta分析,结果显示,两组首视时间的差异无显著性意义(SMD=-0.19,95%CI:-0.46-0.08,P=0.17),见图4A。排除亚组内高异质性文献,采用固定效应模型进行 Meta分析,结果仍然显示,两组首视时间的差异无显著性意义(SMD=-0.19,95%CI:-0.45-0.07,P=0.16),见图4B。 (3)负性情绪图片:共纳入6项研究[17,20-21,23,26-27]。由于研究间异质性较大(I2=54%),故采用随机效应模型进行Meta分析,结果显示,病例组和对照组首视时间的差异无显著性意义(SMD=0.09,95%CI:-0.31-0.48,P=0.66),见图4A。排除LANZA等[23]的研究后异质性消失(I2=0%),提示其为异质性来源。对其他研究汇总并采用固定效应模型进行Meta分析,结果仍然显示差异不具有显著性意义(SMD=0.24,95%CI:-0.04-0.52,P=0.09),见图4B。 2.3.3 注视次数 (1)正性情绪图片:仅有1项研究报道了两组对正性情绪图片的注视次数[28],通过对比发现病例组比对照组对正性情绪图片的注视次数更少(SMD=-3.65,95%CI:-4.59至-2.71,P < 0.000 01),见图5。"
(2)中性情绪图片:共纳入2项研究[17,28]。由于研究间无异质性(I2=0%),故采用固定效应模型进行Meta分析,结果显示,病例组比对照组对中性情绪图片的注视次数更多(SMD=-1.08,95%CI:-1.61至-0.56,P < 0.000 1),见图5。 (3)负性情绪图片:共纳入2项研究[17,28]。由于研究间无异质性(I2=0%),故采用固定效应模型进行Meta分析,结果显示,病例组比对照组对负性情绪图片的注视次数更多(SMD=1.32,95%CI:0.78-1.86,P < 0.000 01),见图5。 2.4 敏感性分析结果 通过逐一剔除纳入研究,进行敏感性分析。在对正性图片注视时间的观察中,见图6A,排除ISAAC等[21]、NEWMAN等[25]及SEARS等[28]3篇文献后,SMD分别变为-0.85(95%CI:-1.79-0.09)、-0.96(95%CI:-1.97-0.05)、-0.52(95%CI:-1.15-0.10),提示正性图片注视时间的结果不稳定。"
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