Dental pulp fibroblasts inducing and regulating dentin-pulp regeneration

doi:10.12307/2021.154

Abstract

Abstract:

BACKGROUND: During pulp-dentin regeneration, other types of cells in dental pulp, such as dentin cells and stem cells, have been widely concerned and studied by scholars, while fibroblasts have been rarely studied. The study on dental pulp fibroblasts may provide a new source of cells for future pulp treatment.
OBJECTIVE: To review the role of dental pulp fibroblasts in pulp-dentin regeneration.
METHODS: The computer was applied to search articles on dental pulp fibroblasts and dental pulp dentine regeneration published from 2000 to 2020 inPubMed and CNKI databases. The English search terms were “pulp, fibroblast, dentin-pulp, regeneration, complement, C5a, C3a”. The Chinese search terms were “dental pulp, fibroblasts, dentin-pulp, complement, C3a, C5a”. Finally, 56 articles were summarized.
RESULTS AND CONCLUSION: Fibroblasts are the most abundant cells in dental pulp. Fibroblasts play an important role in regulating the immune response and function of dental pulp under normal and pathological conditions. They enable complement proteins to produce bioactive fragments, such as C3a, C5a and membrane-attack complexes, and simultaneously, through the secretion of growth factors, fine-regulate the synthesis of restorative dentin, angiogenesis and the distribution of nerve growth, which play an important role in the pulp and dentin regeneration. Therefore, in addition to odontoblasts and pulp stem cells, dental pulp fibroblasts should also be considered as an important cell in the strategy of inducing dentin-pulp regeneration.

Key words: fibroblast, dental pulp, dentin, complement, growth factor, regeneration of dental pulp, C5a, C3a, MAC, review

CLC Number:

Wei Xiaoling, Hu Weiping, Liu Mingyue, Shi Xin, Liu Jie, Gao Li, Wang Siran, Duan Yajun. Dental pulp fibroblasts inducing and regulating dentin-pulp regeneration[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5079-5084.

Figures/Tables 1

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