Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (17): 2657-2663.doi: 10.3969/j.issn.2095-4344.3191
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Wen Shuaibo, Han Jie, Wu Yukun
Received:
2020-05-06
Revised:
2020-05-11
Accepted:
2020-05-30
Online:
2021-06-18
Published:
2021-01-08
Contact:
Han Jie, Master, Associate chief physician, Department of Joints and Sports Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
About author:
Wen Shuaibo, Master candidate, Department of Joints and Sports Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Supported by:
CLC Number:
Wen Shuaibo, Han Jie, Wu Yukun. Bibliometric and visual analysis of literature on cartilage repair in the Web of Science in recent 15 years[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(17): 2657-2663.
2.3 作者可视化分析 应用Citespace软件对文献作者进行共现图谱分析,时间分区设置为1年分区法,形成的图片上每1个点都代表1位作者。发文量排名前5的作者,见表2。其中MAGALI CUCCHIARINI以18篇排名首位。发文量排名2-5位的作者分别为:HENNING MADRY(17篇),ROBERT L MAUCK(15篇),ANA REYRICO(12篇)和DANIEL B F SARIS(12篇)。共被引作者排名前5的分别有:BRITTBERG M(392次),HUNZIKER EB(246次),BUCKWALTER JA(185次)、STEADMAN JR(181次)和PETERSON L(165次),见表3。在作者合作关系方面,HENNING MADRY和ROBERT L MAUCK均在排名的前5位,还存在分别以PHILIPP NIEMEYER,JAMES B RICHARDSON,FARSHID GUILAK,MAURO ALINI,ASBJORN AROEN等学者为核心的小范围内合作研究,见图3。"
2.4 机构研究可视化分析 以机构为网络节点,对纳入研究的机构进行统计分析,绘制研究机构合作知识图谱,共有由222个节点、241条连线组成,见图4。主要是各医学院校的研究机构以及附属医院,软骨修复研究数量排在前5的机构,其中纽约特种外科医院(Hosp Special Surg)以27篇排名首位,排名2-5位的机构依次为:哈佛大学医学院(Harvard Med School)、宾夕法尼亚大学(Unversity of Pennsylvania)、匹兹堡大学(University of Pittsburgh)和拉什大学医学中心(Univ Med Ctr Utrecht)。排名前5的机构发文量占全球研究总数的大部分,均来自美国。在中心度排名前5的机构依次是哈佛大学医学院、匹兹堡大学、拉什大学医学中心、AO达沃斯研究所和斯特德曼菲利普研究所,见表4。 "
综合Citespace软件分析得出的作者和机构图谱来看,美洲地区在软骨修复领域影响力最大,以医疗技术发达的美国为主,发文数量主要集中在医学院校和研究机构。其次,在软骨修复的研究上,中国地区和欧洲地区的发文量也占有很大比重,综上所述,利用Citespace软件对导入文献的各个部分进行拆分整合,这种分析有一定的局限性,但是从整体分析上看,大数据分析的系统性、科学性和前瞻性更强。 2.5 关键词共现及聚类分析结果 应用Citespace软件对软骨修复的相关文献进行关键词共现分析,见图5。从2006年到2020年图谱显示高频关键词显示,关节软骨articular cartilage排在首位,出现了402次,其次是软骨修复(cartilage repair)和间充质干细胞(mesenchymal stem cell)分别为379和314次。关键词中心度排名前5的有:细胞(cell)、生长因子(growth factor)、全层缺损(full thickness defect)、组织工程软骨(tissue engineered cartilage)和骨软骨缺损(osteochondral defect),见表5。 "
应用Citespace中LLR算法分别对软骨修复相关文献的关键词进行聚类分析得出3个聚类图,见图6-8。此3个聚类的结果均表示研究的前沿领域: (1) 标题主题词聚类结果包括:关节软骨再生(articular cartilage regeneration)、关节软骨细胞培养(co-cultured articular chondrocyte)、人骨髓间充质干细胞(human mesenchymal stem cell)、过表达的人成纤维细胞生长因子(overexpressing human fibroblast growth factor)、关节镜提升术(arthroscopic lift)、未成熟软骨碎片(juvenile chondral fragment)、γ谷氨酸(gamma-glutamic acid)、关节腔内给药(intra-articular delivery)、联合基因转移(combined gene transfer)、老鼠受伤模型(mouse injury model) 和骨软骨移植失败(osteochondral grafts failure)。 (2) 关键词聚类结果提示:新生软骨(neocartilage)、软骨(cartilage)、硫氧化物9(sox9)、间充质干细胞(mesenchymal stem cells)、软骨下骨(subchondral bone)、未成熟的(juvenile)、支架(scaffold)、再生医学(regenerative medicine)、临床试验(clinical trialclinical trial) 和软骨修复术后翻修(revision cartilage restoration)。 (3) 摘要主题词聚类结果得到:祖细胞(progenitor cell)、扩增的软骨细胞 (decm-expanded chondrocyte)、无嫁接的聚已内酯膜(ungrafted pcl film)、诱导多能干细胞(IPS cell)、聚羟基乙酸角蛋白水凝胶(pga-keratin hydrogel)、端粒酶活性(telomerase activity)、氯化十六烷吡啶迁移(cpc migration)、人间充质干细胞颗粒(hmsc pellet)和详细评估(careful evaluation)。 "
2.6 关键词突现及时区图分析 突现是指一个变量在短期内发生突然的改变,通过Citespace软件的突现检测共得出36个突现词,文中只列举出突现强度前15位关键词,见表6。时区图分析可以发现每个时间段的关键词,以预测每个时间段的研究热点,见图9。通过突现分析和时区图分析发现,软骨修复的研究大概可以分为3个关键时间段: ①2006至2010年:镶嵌式成形(mosaicplasty)、胶原蛋白(collagen)、表型(phenotype)、关节软骨缺损(articular cartilage defect)、随机试验(randomized trial)、组织工程软骨(tissue engineered cartilage)、全层缺损(full thickness defect)、自体软骨细胞(autologous chondrocyte)、自体软骨细胞移植 (autologous chondrocyte transplantation);②2011至2015年:力学性能(mechanical property)、软骨细胞(articular chondrocyte)、磁共振成像(Mri);③2016至2020年:治疗(therapy)、膝骨关节炎(knee osteoarthritis)、脂肪组织(adipose tissue)、硫氧化物(SOX9)、重组腺相关病毒(RAAV)、矢量分析(vector)、计算机断层扫描(computed tomography)和诊断(integration)等。"
图10显示当前软骨修复的研究主题可分为8大类。其中包含文献较多的3类的聚类标签分别是“blood-derived mesenchymal stem cells(血源间充质干细胞)”、“osteoarthritis(骨关节炎)”以及“rich plasma(富含血浆)”提示其为当前的热点主题。 2.8 研究发展趋势和潜在研究热点 文献共被引共现及突现性分析结果显示,见图11,表10。共有29篇文献具有突现性。按照突现性的时间分布,从2016至2020年出现的突现共被引文章有15篇,文中列举了比较有代表性的文章,文献共被引分析结果表明,在综述类文章方面,MAKRIS EA发表的“关节软骨的修复和组织工程技术”(Repair and tissue engineering techniques for articular cartilage)被引频次为81,此外,在临床研究类文章方面,JO CH发表的“关节内注射间充质干细胞治疗膝关节骨性关节炎:一个概念验证的临床试验”(Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial)被引用51次。详见表10。 "
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