Bibliometric and visual analysis of literature on cartilage repair in the Web of Science in recent 15 years

doi:10.3969/j.issn.2095-4344.3191

Abstract

Abstract: BACKGROUND: Cartilage repair has always been a great challenge for orthopedics doctors all over the world, and it has always been a research hot-spot.
OBJECTIVE: To explore the development status, research hotspots and dynamic frontiers in cartilage repair in the past 15 years based on the bibliometric, co-occurrence, co-citation and visual analysis of relevant literature.
METHODS: Based on the core collection of related documents in the Web of Science (WOS) database from January 1, 2006 to April 6, 2020, CiteSpace software was used for a literature visual analysis.
RESULTS AND CONCLUSION: A total of 1 632 papers were included. The results of co-occurrence analysis, burst analysis and cluster analysis show that cartilage repair belongs to the field of regenerative medicine, and the types of stem cells mainly involved in cell transplantation include human bone marrow mesenchymal stem cells, mesenchymal stem cells, artificial multi-functional stem cells, adipose tissue derived stem cells. It can be seen that stem cells are the research focus in the past, present or future. Treatments for cartilage repair include autograft chondrocyte transplantation, mosaic plasty, tissue-engineered cartilage implantation, intraarticular administration, combined gene transfer, which are widely used at present. Factors influencing gene expression include overexpressed human fibroblast growth factor, expanded chondrocytes, sulfur oxide 9, recombinant adeno-associated virus, γ- glutamic acid, cetylpyridinium chloride, mechanical properties, and telomerase activity. These biocompatible materials and factors of culture medium can guide gene carriers in cartilage repair, which is a hot topic in the future. Tissue engineering technology such as polycaprolactone membrane, polyglycolic acid keratin hydrogel and other tissue engineering materials used for mesenchymal stem cell transplantation is the current research trend. The above results show that through the application of CiteSpace software for bibliometric and visual analysis, we can intuitively see the development of cartilage repair in the past 15 years, mainly revealing that stem cell therapy for cartilage defects, different biocompatible materials and different gene transfer technologies for cartilage repair are the current research hots and the developmental trends of cartilage repair, providing different ideas and research directions of animal experiments and clinical trials for domestic scientific research and clinical workers.

Key words: cartilage, repair, joint, stem cells, gene, CiteSpace, bibliometrics, visual analysis

CLC Number:

Wen Shuaibo, Han Jie, Wu Yukun. Bibliometric and visual analysis of literature on cartilage repair in the Web of Science in recent 15 years[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(17): 2657-2663.

Figures/Tables 21

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