Anesthesia management for aortic valve plus mitral valve replacement in Small-Tailed Han sheep

doi:10.3969/j.issn.2095-4344.1064

Abstract

Abstract:

BACKGROUND: At present, there are few studies on the anesthetic methods for cardiac surgeries in Small-Tailed Han sheep, and further experimental verifications on the effectiveness and safety are still required.
OBJECTIVE: To evaluate the safety and effectiveness of anesthetic methods for cardiac surgeries in Small-Tailed Han sheep.
METHODS: Forty Small-Tailed Han sheep, aged (10.95±0.89) months, weighing (71.3±7.7) kg, underwent aortic valve plus mitral valve replacement after basic anesthesia with intramuscular ketamine (8-12 mg/kg)+scopolamine (10-20 μg/kg) or with intravenous ketamine (2.5-3.5 mg/kg)+scopolamine (10-15 μg/kg) and general anesthesia with intravenous propofol and fentanyl. The bucking response in endotracheal intubation, vital signs, hemodynamic changes, recovery condition and complications were observed during the perioperation (5 minutes before incision, 5 minutes after incision, 5 minutes before in vitro transfer, 5 minutes after in vitro shutdown, immediately after surgery, 1 day after surgery).
RESULTS AND CONCLUSION: None of the animals failed in intubation. Perioperative sedation and analgesia were satisfactory, and vital signs were stable; perioperative blood gas analysis shows stable internal environment; no body movement occurred, and all cases well tolerated valve replacement; no regurgitation and aspiration occurred during operation; and there were no deaths during the procedure. Anesthesia with propofol and isoflurane plus low-dose fentanyl has the advantages of rapid recovery, stable hemodynamics and good anesthetic effect, which is a safe and effective anesthesia scheme for cardiac surgery in Small-Tailed Han sheep.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Anesthesia, Sheep, Aortic Valve, Mitral Valve, Tissue Engineering

CLC Number:

R446
R318

Peng Xianjiang1, Liu Bozhi2, Duan Haifeng1, Yang Qianzi1, Hu Sheng1 . Anesthesia management for aortic valve plus mitral valve replacement in Small-Tailed Han sheep[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(7): 1052-1056.

Figures/Tables 1

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