Effects of flow rate and blade outlet width on hemolytic performance of centrifugal blood pump

doi:10.3969/j.issn.2095-4344.1604

Abstract

Abstract:

BACKGROUND: Hemolysis is an important problem in the design and development of artificial heart pumps. Hemolysis is associated with the shear force of blood cells in the pump and the movement time in the pump.

OBJECTIVE: To analyze the relationship between the operating parameters of blood pump (flow rate of blood pump), the structure of blood pump (outlet width of blade) and the shear stress of blood cells in artificial heart pump.

METHODS: The basic structure of the centrifugal blood pump was designed according to the velocity coefficient method. The three-dimensional model of the blood pump, mesh division and flow field simulation were established by using CFturbo, ANSYS ICEM and FLUENT software respectively to study the best mesh division method. The results of the numerical simulation corrected the diameter of the impeller outlet to finally obtain an artificial heart pump meeting the needs of the human heart. In order to reduce the shear stress and movement time of blood cells in the heart pump, the optimal design and analysis of the impeller inlet flow rate Q (2, 3, 4, 5, 6, 7 L/min) and the operating parameter blade outlet width b₂ (2.0, 2.1, 2.2, 2.3, 2.4, 2.5 mm) of the centrifugal artificial heart pump were designed to reduce the probability of hemolysis.

RESULTS AND CONCLUSION: (1) As the flow rate increased, the shear stress of the blood cells in the blood pump gradually increased, and the movement time gradually decreased. As the flow rate increased, the standard hemolysis value in the blood pump gradually decreased, and the damage to the blood cells in the blood pump alleviated. When the flow rate was 7 L/min, the standard hemolysis value in the blood pump was the lowest. (2) With the increase of blade outlet width, the shear stress of the blood in the pump decreased, and the movement time of the blood in the pump increased. When the blade outlet width was 2.0-2.5 mm, the hemolysis value in the blood pump decreased with the increase of the blade outlet width. When the blade outlet width was about 2.5 mm, the hemolysis value in the blood pump was the lowest.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Heart Transplantation, Hemolysis, Hemodynamics, Tissue Engineering

CLC Number:

Hu Wanqian, Li Xuemin, Xu Lin, Liu Jiwei, Sun Hao. Effects of flow rate and blade outlet width on hemolytic performance of centrifugal blood pump[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(10): 1581-1587.

Figures/Tables 4

References

[1] 陈伟伟,高润霖,刘力生,等.中国心血管病报告2017概要[J].中国循环杂志,2018,33(1):1-8.

[2] 宋云虎,胡盛寿,董念国,等.中国心脏移植现状[J].中国循环杂志, 2016,31(z1):77-77.

[3] Isomura T, Fukada Y, Miyazaki T,et al. Posterior ventricular restoration treatment for heart failure: a review, past, present and future aspects.Gen Thorac Cardiovasc Surg. 2017;65(3): 1-7.

[4] 张岩,孙寒松,胡盛寿.左心室辅助血泵及其临床应用研究进展[J].中国胸心血管外科临床杂志, 2017,24(2):152-155.

[5] Muslem R,Caliskan K,Leebeek FWG. Acquired coagulopathy in patients with Left Ventricular Assist Devices. J Thromb Haemost.2018;16(3):429-440.

[6] 寿宸,郭勇君,苏磊,等.基于快速溶血预估模型的离心血泵叶轮特性数值分析[J].生物医学工程学杂志, 2014,31(6):1260-1264.

[7] 王芳群.应用 CFD 技术探明叶轮设计对人工心脏血泵内流场及切应力分布的影响[D].镇江:江苏大学,2003.

[8] 陈松松.基于溶血估算的离心血泵设计[D].杭州:浙江大学, 2011.

[9] 李卫东,姚奇,杜建军,等.基于 CFD 的液悬浮人工心脏泵叶轮入口优化分析[J].北京生物医学工程,2017, 36(1):21-28.

[10] Takami Y,Nakazawa T,Makinouchi K,et al. Hemolytic effect of surface roughness of an impeller in a centrifugal blood pump. Artif Organs.1997;21(7):686-690.

[11] Umezu M,Yamada T,Fujimasu H,et al.Effects of surface roughness on mechanical hemolysis. Artif Organs. 1996; 20(5):575-578.

[12] Heck ML,Yen A,Snyder TA,et al.Flow-Field Simulations and Hemolysis Estimates for the Food and Drug Administration Critical Path Initiative Centrifugal Blood Pump.Artif Organs. 2017; 41(10): 129-140.

[13] da Silva C,da Silva BU,Leme J,et al.In Vivo Evaluation of Centrifugal Blood Pump for Cardiopulmonary Bypass—Spiral Pump.Artif Organs.2013;37(11):954-957.

[14] Chiu WC,Slepian MJ,Bluestein D.Thrombus Formation Patterns in the HeartMate II VAD-Clinical Observations Can Be Predicted by Numerical Simulations. ASAIO J. 2014;60(2): 237-240.

[15] Wernicke JT,Meier D,Mizuguchi K,et al.A fluid dynamic analysis using flow visualization of the Baylor/NASA implantable axial flow blood pump for design improvement. Artif Organs. 1995; 19(2):161-177.

[16] Reich HJ,Morgan J,Arabia F,et al.Comparative analysis of von Willebrand Factor profiles after implantation of left ventricular assist device and total artificial heart.J Thromb Haemost. 2017; 15(8):1620-1624.

[17] Akamatsu T, Nakazeki T, Itoh H. Centrifugal blood pump with a magnetically suspended impeller. Artif Organs. 1992;16(3): 305-308.

[18] Wu J, Paden BE, Borovetz HS, et al. Computational fluid dynamics analysis of blade tip clearances on hemodynamic performance and blood damage in a centrifugal ventricular assist device. Artif Organs.2010;34(5):402-411.

[19] Daisuke S, Tomotaka M, Ryo K, et al. Real-Time Observation of Thrombus Growth Process in an Impeller of a Hydrodynamically Levitated Centrifugal Blood Pump by Near-Infrared Hyperspectral Imaging. Artif Organs. 2015; 39(8): 714-719.

[20] Carpentier A,Latrémouille C,Cholley B,et al.First clinical use of a bioprosthetic total artificial heart: report of two cases. Lancet. 2015;386(10003):1556-1563.

[21] Song G, Chua LP, Lim TM.Numerical Study of a Bio‐Centrifugal Blood Pump With Straight Impeller Blade Profiles. Artif Organs.2010;34(2):98-104.

[22] Leme J,Silva C,Fonseca J,et al. Centrifugal blood pump for temporary ventricular assist devices with low priming and ceramic bearings.Artif Organs.2013;37(11):942-945.

[23] Özalp F,Bhagra S,Bhagra C,et al.Four-year outcomes with third-generation centrifugal left ventricular assist devices in an era of restricted transplantation.Eur J Cardiothorac Surg. 2014; 46(3):35-40.

[24] Miller JR, Lawrance CP, Silvestry SC. Current Options and Practices in Long-Term Ventricular Assist Devices.Curr Surg Rep.2014;2(5):1-9.

[25] Velicki L, Frazier OH. Long-term ventricular assist devices in current clinical practice. Vojnosanit Pregl.2013;70(7):679.

[26] Sun P, Leng W, Zhang CS, et al.ALE Method for a Rotating Structure Immersed in the Fluid and Its Application to the Artificial Heart Pump in Hemodynamics[C]//International Conference on Computational Science.Springer,Cham, 2018: 9-23.

[27] Bente T, Bastian B, Jens S, et al. Numerical Analysis of Blood Damage Potential of the eart Mate II and Heart Ware HVAD Rotary Blood Pumps.Artif Organs.2015;39(8):651-659.

[28] Apel J, Paul R, Klaus S, et al. Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics.Artif Organs. 2001;25(5):341-347.

[29] Garon A, Farinas MI. Fast Three‐dimensional Numerical Hemolysis Approximation. Artif Organs.2004; 28(11): 1016-1025.

[30] 谢雄,谭建平,刘云龙.轴流式血泵流体特性CFD研究[J].工程设计学报,2014,21(2):154-160.

[31] 牛彦文.人工心脏泵叶轮结构参数优化及有限元分析[D].哈尔滨:哈尔滨工业大学,2016.

[32] Sakota R, Lodi CA, Sconziano SA, et al. In Vitro Comparative Assessment of Mechanical Blood Damage Induced by Different Hemodialysis Treatments. Artif Organs. 2015;39(12): 1015-1023.

[33] 王立群.我国开展心衰终末期治疗新技术(127)[J].临床心电学杂志, 2018,27(1):73.

[34] McIlvennan CK,Magid KH,Ambardekar AV,et al.Clinical outcomes after continuous-flow left ventricular assist device: a systematic review. Heart Fail.2014;7(6):1003-1013.

[35] Schmitto JD, Hanke JS, Rojas SV, et al. First implantation in man of a new magnetically levitated left ventricular assist device (HeartMate III). J Heart Lung Transplant. 2015;34(6): 858-860.

[36] 胡盛寿.心力衰竭外科治疗现状与进展[J].中国循环杂志, 2016, 31(3):209-213.

[37] 李卫东.离心式人工心脏泵血流动力学特性分析与优化研究[D].哈尔滨:哈尔滨工业大学,2016.

[38] Szwast M, Moskal A, Piatkiewicz W. A new method for assessing haemolysis in a rotary blood pump using large eddy simulations(LES).Chem Proc Eng.2017;38(2):231-239.

[39] Telyshev D,Denisov M,Pugovkin A,et al. The Progress in the Novel Pediatric Rotary Blood Pump Sputnik Development. Artif Organs.2018;42(4):432-443.

[40] Murashige T,Kosaka R,Sakota D,et al.Evaluation of a spiral groove geometry for improvement of hemolysis level in a hydrodynamically levitated centrifugal blood pump. Artif Organs. 2015;39(8):710-714.