Chinese Journal of Tissue Engineering Research ›› 2018, Vol. 22 ›› Issue (26): 4235-4240.doi: 10.3969/j.issn.2095-4344.0764

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Physical guidance cues of nerve conduits

Xiang Yang1, Wu Yi-bing1, Wei Peng1, Yin Jun2, Dai Guang-li1   

  1. 1Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China; 2Zhejiang University, Hangzhou 310000, Zhejiang Province, China
  • Received:2017-12-23
  • Contact: Dai Guang-li, Engineer, Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China
  • About author:Xiang Yang, Master, Physician, Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China
  • Supported by:

     the National Natural Science Foundation of China, No. 11402056; the Second-Batch Scientific Research Program of Ningbo City, No. 2017A610215

Abstract:

BACKGROUND: A tissue-engineered nerve conduit for peripheral nerve repair is a popular alternative to peripheral nerve repair recently. Adding various physical guidance cues result in better outcome of regeneration of defected nerve.

OBJECTIVE: To conclude the physical guidance cues in two aspects, including conduit luminal wall property and intralluminal guidance structures.
METHODS: We searched WanFang database and Web of Science database for relevant literature published from 1980 to 2017 using the keywords of “tissue engineering; nerve conduit; peripheral nerve; injury; scaffold; topological cues” in Chinese and English, respectively.

RESULTS AND CONCLUSION: Autograft and allograft are two main methods for peripheral nerve repair, but both of them have some inescapable disadvantages. Tissue-engineered nerve conduit as a scaffold bridging the nerve gap overcomes the above-mentioned disadvantages. In relative experiments, the introduction of physical guidance cues to the nerve conduit is proved to improve nerve regeneration. If physical guidance cues within nerve conduit achieve an optimal balance, the tissue-engineered nerve conduit with the introduction of biochemical guidance cues will achieve optimal outcome in nerve regeneration, and thus it seems to be the first choice for peripheral nerve repair in the future.

 

Key words: Biocompatible Materials, Peripheral Nerves, Tissue Engineering

CLC Number: