Tissue-engineered cartilage implantation for the treatment of full-thickness knee cartilage defects

doi:10.3969/j.issn.2095-4344.0745

Abstract

Abstract:

BACKGROUND: The use of normal hyaline cartilage to repair large areas of full-thickness knee cartilage defect has been a hot topic recently; however, a follow-up study with a relative large number of patients is required.

OBJECTIVE: To make a preliminary study concerning the methods and therapeutic effects of tissue-engineered cartilage (TEC) implantation for treating large-area full-thickness knee cartilage defects.

METHODS: Twenty-one patients (23 knees) diagnosed with cartilage defect of the knee joint (Outbridge III-IV) were enrolled. The area of the cartilage defect was 3.5-11.2 cm². All of the patients were given TEC treatment. Postoperative functional exercise of the knee joint was carried out in these patients as planned. We regularly reviewed the knee MRI and calculated visual analog scale score, International Knee Documentation Committee (IKDC) score, and Lysholm score.

RESULTS AND CONCLUSION: All the patients were followed up for 3 to 12 months. Postoperatively knee pain relieved obviously, and the visual analog scale score was significantly declined compared with the preoperation (P < 0.05). All the patients manifested painless 1 year after surgery. The 1-year postoperative MRI showed that the injured cartilage grew well. The thickness and MRI signal of the graft was the same as the normal cartilage, and the bone healed completely. The IKDC and Lysholm scores were significantly improved at 3, 6, 12 months after the surgery, and the difference was statistically significant before and after the surgery (P < 0.05). Overall, TEC is an improved technique of chondrocyte implantation, which is an effective and safe method for cartilage defect repair.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Knee Joint, Cartilage

CLC Number:

R318

Feng Wen-zhe, Lu Wei, Xu Jian, Zhu Wei-min, Ouyang Kan, Peng Liang-quan, Liu Hai-feng, Li Hao, Chen Kang, Li Ying. Tissue-engineered cartilage implantation for the treatment of full-thickness knee cartilage defects[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(14): 2152-2156.

Figures/Tables 3

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