Abstract:

BACKGROUND: Evidence exists that nutrition of bone marrow mesenchymal stem cells plays an important role in the treatment of spinal cord injury. The interaction between bone marrow mesenchymal stem cells and damaged host nerve tissue can reduce the expression of inflammatory cytokines which is conductive to injury recovery.
OBJECTIVE: To explore the effect of intravenous transplantation of bone marrow mesenchymal stem cells on the expression of tumor necrosis factor-α and interleukin 1β after spinal cord injury in rats.
METHODS: The T10 paraplegia model of rat spinal cord injury was prepared using modified Allen. The experiment was divided into control group and transplantation group. The sham operation group with no spinal cord injury was designated. The transplantation group and sham operation group were given intravenous administration of bone marrow mesenchymal stem cells, the same concentration of PBS was intravenously injected into the control group.
RESULTS AND CONCLUSION: Expression of tumor necrosis factor-α and interleukin 1β protein in the transplantation group and control group was higher than that in the sham operation group (P < 0.05). Compared with the control group, the expression of tumor necrosis factor-α and interleukin 1β protein in the transplantation group was significantly inhibited (P < 0.05). Intravenous transplantation of bone marrow mesenchymal stem cells could reduce the expression of tumor necrosis factor-α and interleukin 1β in the injured area of spinal cord. Maybe it was one of the mechanisms to change the microenvironment of the injured area, decrease the secondary spinal cord injury and promote the recovery of motor function in spinal cord injury rats.