Minocycline hydrochloride ointment is available for the treatment of peri-implantitis

doi:10.3969/j.issn.2095-4344.0058

Abstract

Abstract:

BACKGROUND: In recent years, the topical use of antibiotics in periodontal pockets has become a new regimen for the prevention and treatment of peri-implantitis.

OBJECTIVE: To analyze the effectiveness of minocycline hydrochloride ointment in the treatment of peri-implantitis.

METHODS: Eighty cases of peri-implantitis, 38 males and 42 females, aged 20-32 years, were divided into two groups: experimental group (n=40) was given minocycline hydrochloride ointment into the bottom of periodontal pockets, once a week; and control group (n=40) was injected iodine glycerol into the bottom of periodontal pockets, once a week. Meanwhile, patients without peri-implantitis were selected as normal control group (n=40). After 4 weeks of treatment, we detected probing index, bleeding index, plaque index, detection of Prevotella melaninogenica and Streptococcus oralis in the two groups, and then statistically analyzed the clinical efficacy.

RESULTS AND CONCLUSION: (1) Before the treatment, probing index, bleeding index, plaque index, and detection rates of Prevotella melaninogenica and Streptococcus oralis were all higher in the experimental group than the normal control group (P < 0.05), but there was no significant difference between the experimental group and the control group. (2) After 4 weeks of treatment, probing index, bleeding index, plaque index, and detection rates of Prevotella melaninogenica and Streptococcus oralis in the experimental and control groups were significantly lowered (P < 0.05), but still higher than those in the normal control group (P < 0.05). In addition, these indices were also significantly lower in the experimental group than the control group (P < 0.05). (3) The clinical efficiency of the experimental group after treatment was significantly higher than that of the control group (98% vs. 75%, P < 0.05). Taken together, minocycline hydrochloride ointment as an effective treatment for peri-implantitis can inhibit the colonization of Prevotella melaninogenica and Streptococcus oralis.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Dental Implants, Minocycline, Tissue Engineering

CLC Number:

R318

Liu Ou, Gao Zhu, Li Tao, Zhou Bo. Minocycline hydrochloride ointment is available for the treatment of peri-implantitis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(6): 852-857.

Figures/Tables 11

References

[1]沈琳,彭国光,夏炜,等.口腔种植修复失败原因探讨[J].中国口腔种植学杂志,2014,19(2):84-87.

[2]孙志新,张云涛.口腔种植体周围炎与白细胞介素间的关系[J].国际口腔医学杂志,2015,42(2):221-224.

[3]RoosJansåker AM,Persson GR,Lindahl C,et al.Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: a 5-year follow-up.J Clin Periodontol.2014;41(11):1108-1114.

[4]韩月红,成之远,王明德.氧化锆陶瓷与镍铬合金口腔材料的细菌黏附性对比[J].中国组织工程研究,2016, 20(8):1089-1094.

[5]Meng H.Peri-implantitis: risk factors, prevention and treatment.Chin J Stomatol.2014;49(6):328-332.

[6]李浪,马锦华,吴亚菲.盐酸米诺环素软膏治疗慢性牙周炎的临床研究[J].现代药物与临床,2015,30(5):531-534.

[7]Veitz-Keenan A,Keenan JR.Antibiotic use at dental implant placement.Evid Based Dent.2015;16(2):50-51.

[8]Hiraoka R,Sasaki M,Matsushita Y,et al.Mechanical Evaluation of Surrounding Bone with Bone Resorption Model Simulating Peri-Implantitis.Journal of Japanese Society of Oral Implantology. 2014;27:321-330.

[9]Arduino PG,Tirone F,Schiorlin E,et al.Single preoperative dose of prophylactic amoxicilin versus a 2-day postoperative course in dental implant surgery:a two-centre randomised controled trial.Eur J Oral Implantol.2015;8(2):143-149.

[10]孟田甜,李新.牙龈卟啉单胞菌与病毒的交互作用[J].华西口腔医学杂志,2016,34(4):425-427.

[11]王珏,焦艳军,杜晓红,等.牙周炎患者种植修复后可疑致病菌的变化研究[J].现代口腔医学杂志, 2014(6):327-330.

[12]熊萍,唐运涛,陈宏刚,等.种植体龈下菌群构成情况分析[J].现代预防医学,2014,41(19):3618-3620.

[13]Rams TE,Degener JE,van Winkelhoff AJ.Antibiotic resistance in human peri-implantitis microbiota.Clin Oral Implants Res. 2014;25(1):82-90.

[14]倪欢胜,王镶珊,韩翔,等.口腔种植体周围菌群分布及耐药性分析[J].中华医院感染学杂志,2014, 24(3):594-595.

[15]Fritoli A,Goncalves C,Faveri M,et al.The effect of systemic antibiotics administered during the active phase of non-surgical periodontal therapy or after the healing phase: a systematic review. J Appl Oral Sci.2015;23(3):249-254.

[16]王萃萃.盐酸米诺环素软膏联合甲硝唑药膜治疗牙周病的临床观察[J].北方药学,2015,12(10):63.?

[17]陈新,谭新伟,刘洪臣,等.盐酸米诺环素联合替硝唑治疗 2 型糖尿病合并牙周病的临床研究[J].现代药物与临床,2014,29(6): 664-667?.

[18]张红艳,胡迎新,崔粲,等.甲硝唑药膜联合盐酸米诺环素软膏治疗牙周病的临床疗效分析[J].现代生物医学进展,2017, 17(4): 746-749.

[19]Zhang H,Yang X,Li C,et al.Effects of minocycline-HCl paste root conditioning on periodontal surgery: in vitro and in vivo studies.Int JClin Exp Med.2015;8(3):4080-4086.

[20]马晶.盐酸米诺环素软膏治疗牙周炎患者的临床疗效[J].临床药学,2017,12(1):62-64.

[21]毛小琴,周光,张樱,等.不同耐药表型鲍氏不动杆菌的蛋白质表达图谱的建立研究[J].中华医院感染学杂志, 2014,24(2):261-263.

[22]Chiappe VB,Gómez MV,Rodríguez C,et al.Subgingivally applied minocycline microgranules in subjects with chronic periodontitis: A randomized clinical and microbiological trial.Acta Odontológica Latinoamericana Aol.2015;28(2): 122-131.

[23]肖艳,谭小兵,徐静舒.米诺环素辅助治疗侵袭性牙周炎对血清炎性因子的影响[J].重庆医学, 2015,44(9):1208-1210.

[24]杜艳,陈正辉,陈瑞春,等.2012年中国云南地区革兰阴性杆菌耐药监测[J].中国抗生素杂志,2014, 39(8):629-634.

[25]何艳阳.奥硝唑碘甘油糊剂治疗急性智齿冠周炎对冠周袋内菌群的影响及疗效分析[J].中国微生态学杂志, 2015,27(9): 1041-1043.

[26]顾明,廖天安,邢孔才,等.牙周炎患者局部应用盐酸米诺环素软膏与碘甘油的临床效果对比研究[J].现代生物医学进展,2013, 13(29):5761-5764.

[27]胡瑶瑶.盐酸米诺环素在种植体周围炎中的应用[J].临床合理用药,2017,3(10):108-109.

[28]刘敏,曲进.盐酸米诺环素缓释剂治疗老年牙周炎的疗效[J].中国老年学杂志,2011,31(17):3223-3224.

[29]徐燕.盐酸米诺环素治疗种植体周围黏膜炎疗效观察[J].中国美容医学,2017,6(26):72-74.