Protective effect of nano-carbon tracers on the parathyroid glands

doi:10.3969/j.issn.2095-4344.2016.30.010

Abstract

Abstract:

BACKGROUND: So far there are many studies about the uses of nano-carbon tracers in the diagnosis and treatment of malignancies. However, little has been reported on the mechanism underlying protective effect of nano-carbon tracers on the parathyroid glands during thyroid cancer surgery.
OBJECTIVE: To study the protective effect of nano-carbon tracers on the parathyroid in thyroid cancer surgery.
METHODS: 180 cases of thyroid cancer were randomly divided into nano-carbon and control groups (n=90 per group): patients in the nano-carbon group were injected with nano-carbon tracers into the thyroid before surgery, and those in the control group underwent routine thyroid cancer surgery. Then comparisons of the operating time, incision length, blood loss, postoperative hospital stay, number of lymph node dissection, lymph node metastasis as well as hypoparathyroidism rate were performed between two groups. Besides, levels of serum calcium and parathyroid hormone in the two groups were detected at 3 days after surgery.
RESULTS AND CONCLUSION: There were no significant differences in the operating time, incision length, blood loss, postoperative hospital stay and lymph node metastasis between the two groups (P > 0.05). The number of dissected lymph nodes of nano-carbon group was significantly higher than that of control group (P < 0.05); the mis-resection rate of parathyroid and hypoparathyroidism of nano-carbon group were significantly lower than those of control group (P < 0.05). Furthermore, the incidences of hypocalcemia and low parathyroid hormone of nano-carbon group were significantly lower than those of control group (P < 0.05). These results suggest that the nano-carbon tracer plays a protective role on the parathyroid glands in thyroid cancer surgery, which can reduce the mis-resection rate of parathyroid, as well as the incidences of hypoparathyroidism, hypocalcemia and low-level parathyroid hormone.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Thyroid Neoplasms, Parathyroid Glands, Tissue Engineering

CLC Number:

R318

Chen yong, Shan Wei-ying. Protective effect of nano-carbon tracers on the parathyroid glands[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(30): 4476-4482.

Figures/Tables 8

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