Preconditioning strategies for promoting mesenchymal stem cell homing

doi:10.3969/j.issn.2095-4344.2016.28.019

Abstract

Abstract:

BACKGROUND: Homing is the initial and key procedure of stem cells-based tissue restoration. Current studies have shown that the inability to recruit bone marrow mesenchymal stem cells to target tissue with high efficiency remains a significant barrier to tissue restoration. Preconditioning strategy provides a new insight to promote stem cell homing.
OBJECTIVE: To review preconditioning strategies for promoting the homing of stem cells.
METHODS: In PubMed database, different combinations of terms from “stem cell, mesenchymal stem cells, preconditioning, homing, migration” served as search terms to retrieve articles referring preconditioning strategies for promoting mesenchymal stem cell homing published from January 2000 to September 2015. According to the inclusion criteria, 72 articles were selected for final review.
RESULTS AND CONCLUSION: Pretreating target tissue or mesenchymal stem cells ahead of cell transplantation, known as tissue preconditioning or cell preconditioning, prominently promotes the homing of mesenchymal stem cells, therefore enhancing tissue restoration effect. Tissue preconditioning is designed to up-regulate expression of chemokines by varying the local microenvironment, thereby increasing homing ability of mesechymal stem cells. Mesenchymal stem cell preconditioning strategies, for example, gene modification and cytokine induction, are mainly to up-regulate expression of chemokine receptors on the surface of mesenchymal stem cells as effectors, and thus promote targeted cell homing. Overall, preconditioning strategy will bring great hope to apply stem cell therapy into the clinic.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Mesenchymal Stem Cells, Transplantation, Tissue Engineering

CLC Number:

R394.2

Wang Guo-ren, Bai Zhi-ming . Preconditioning strategies for promoting mesenchymal stem cell homing[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(28): 4234-4242.

Figures/Tables 1

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