Systematic evaluation of extracorporeal bioartificial liver support system for the treatment of liver failure

doi:10.3969/j.issn.2095-4344.2013.18.020

Abstract

Abstract:

BACKGROUND: Bioartificial liver support system is composed of the bioreactors and the cellular materials, which could partially replace the major liver functions, including detoxification, synthesis, secretion and biotransformation.
OBJECTIVE: To overview and evaluate the current clinical effect of extracorporeal bioartificial liver support system for the treatment of liver failure over the past 15 years.
METHODS: Relevant clinical studies from 1995 to 2009 were retrieved from PubMed database and Cochrane Library database. Enrolled studies included randomized controlled trials, controlled clinical trials and case reports.
RESU LTS AND CONCLUSIONS: Thirty-one studies were included. There was a trend of falling into the normal ranges with the clinical and biochemical parameters after bioartificial liver support system treatment. The neurological status of most patients was improved or stabilized during bioartificial liver support system treatment as well. No significant effect on survival rate could be seen after bioartificial liver support system treatment. Although, bioartificial liver support system has proved to be a success in some clinical cases, it still needs to be improved greatly in many aspects.

Key words: organ transplantation, evidence-based medicine of organ transplantation, artificial organ, bioartificial liver, liver failure, clinical trial, systematic review, biochemical parameters

CLC Number:

R318

Gu Jin-yang, Shi Xiao-lei, Ren Hao-zhen, Xiao Jiang-qiang, Ding Yi-tao. Systematic evaluation of extracorporeal bioartificial liver support system for the treatment of liver failure[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(18): 3374-3380.

Figures/Tables 3

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