Efficacy and characteristics of parecoxib and celecoxib in
the treatment of pain after orthopedic surgery: a meta-analysis

doi:10.3969/j.issn.2095-4344.2489

Abstract

Abstract:

BACKGROUND: Improper management of postoperative pain will seriously affect the recovery of patients, leading to a high disability rate. Celecoxib and parecoxib are selective cyclooxygenase 2 inhibitors, and have good analgesic effects. However, there is no comparison between the two in the treatment of postoperative pain in orthopedics department.

OBJECTIVE: To systematically evaluate the efficacy of parecoxib and celecoxib in the treatment of postoperative pain in orthopedic surgery.

METHODS: Databases including CNKI, CBM, Wanfang Data, PubMed and the Cochrane Library were searched from inception to June 2019. The randomized controlled trials regarding the efficacy of parecoxib versus celecoxib in the treatment of pain after orthopedic surgery were collected. Data were extracted and the quality of the study was evaluated. RevMan 5.3 software and Stata 12.0 software were used for result analysis.

RESULTS AND CONCLUSION: (1) Seven randomized controlled trials were involved, containing 524 patients undergoing orthopedic surgery. The experimental group was treated with parecoxib and the control group with celecoxib. (2) Meta-analysis results showed that at 24, 48 and 72 hours after surgery, compared with celecoxib, parecoxib significantly reduced visual analogue scale scores [MD=-0.86, 95%CI=(-1.30, -0.42), P=0.000 1; MD=-0.81, 95%CI=(-1.43, -0.20), P=0.009; MD=-0.32, 95%CI=(-0.48, -0.17), P < 0.000 1], and decreased the dosage of central analgesics [SMD=-2.12, 95%CI=(-2.90, -1.34), P < 0.000 01]. (3) Results suggested that compared with celecoxib, parecoxib significantly reduced postoperative pain and the dose of central analgesics after orthopedic surgery.

Key words: paracoxib, celecoxib, orthopedic surgery, pain, analgesic, randomized controlled trial, meta-analysis, systematic review

CLC Number:

Deng Jinman, Fang Guanjun, Wang Yu, Ding Shaobo. Efficacy and characteristics of parecoxib and celecoxib in the treatment of pain after orthopedic surgery: a meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(9): 1471-1476.

Figures/Tables 8

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