Tissue microarray detection for astrocyte elevated gene-1 and its correlation with pathological factors in primary hepatocellular carcinoma

doi:10.3969/j.issn.2095-4344.2015.20.006

Abstract

Abstract:

BACKGROUND: Astrocytes elevated gene-1 is an important molecular marker for early tumor metastasis, which is likely to become the molecular target in the clinical treatment of hepatocellular carcinoma.
OBJECTIVE: To investigate the astrocyte elevated gene-1 expression level in the tumor tissues of patients with hepatocellular carcinoma, and to predict its role in the minimally invasive therapy.
METHODS: Tissue microarray and immunohistochemistry methods were applied to detect astrocyte elevated gene-1 protein expression level in the tumor tissues of patients with hepatocellular carcinoma, and their clinical-pathological data were collected for correlation analysis with the astrocyte elevated gene-1 protein expression level.
RESULTS AND CONCLUSION: The protein expression level of astrocyte elevated gene-1 was closely related to clinical stage and tissue differentiation degree in patients with hepatocellular carcinoma. In addition, the high expression of astrocyte elevated gene-1 protein was correlated with the positive rate of Ki-67 and tumor micro-vessel density. However, the protein expression had no correlation with gender and age in these patients.
Taken together, the protein expression level of astrocyte elevated gene-1 is correlated with conventional malignant indexes, which is of great significance for the judgment of hepatocellular carcinoma.

Key words: Carcinoma, Hepatocellular, Microchip Analytical Procedures, Ki-67 Antigen, Carcinoma

CLC Number:

R318

Li Cong, Zhang Wei, Liu Xue-zhi, Liu Bo-jun, Zhang Hong-hai, Yang Geng-xia, Sheng Shou-peng, Sun Yu, Yuan Chun-wang, Zheng Jia-sheng. Tissue microarray detection for astrocyte elevated gene-1 and its correlation with pathological factors in primary hepatocellular carcinoma [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(20): 3147-3151.

Figures/Tables 4

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