Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (13): 2068-2073.doi: 10.3969/j.issn.2095-4344.2061
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Liu Ting, Yang Tingting, Ma Xiaona, Ma Haibin, Jin Yiran, Liang Xueyun
Received:
2019-09-03
Revised:
2019-09-05
Accepted:
2019-10-21
Online:
2020-05-08
Published:
2020-03-10
Contact:
Liang Xueyun, Associate researcher, Master’s supervisor, Ningxia Human Stem Cell Institute, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
About author:
Liu Ting, Master, Assistant researcher, Ningxia Human Stem Cell Institute, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Supported by:
CLC Number:
Liu Ting, Yang Tingting, Ma Xiaona, Ma Haibin, Jin Yiran, Liang Xueyun. Immunoregulation of allograft rejection: a role played by human CD200+ sub-population from human placenta-derived mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(13): 2068-2073.
2.2 实验动物数量分析 18只实验受体小鼠,全部进入结果分析,中途无脱落。 2.3 移植物形态学观察结果 细胞治疗后观察各组小鼠的神态、饮食、运动均良好。对照组小鼠术后浑身出汗发抖,三四天即出现移植物发黑变硬,逐步大面积坏死;PMSCs组小鼠5 d左右移植物开始变色发黑,弹性变差,边缘变硬翘起,局部皮片翘起脱落并有较多黄色瘢痕;CD200+-PMSCs组小鼠6 d左右移植物变色发硬,边缘发硬,有部分黄色瘢痕,见图2。根据表2统计分析,PMSCs组、CD200+-PMSCs组小鼠比对照组小鼠移植物的存活时间明显增长(P < 0.001),而CD200+-PMSCs组的增长效果强于PMSCs组(P < 0.01)。 "
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