Application of autologous hard palate mucosa in the eyelid reconstruction

doi:10.3969/j.issn.2095-4344.2017.12.020

Abstract

Abstract:

BACKGROUND: Autologous hard palate mucosa has been validated to be a substitute of the tarsal conjunctival.
OBJECTIVE: To investigate the treatment outcomes of autologous hard palate mucosa applied in the eyelid reconstruction.
METHODS: 180 patients (180 eyes) with eyelid defects aged 10-63 years old were recruited, including 122 males and 58 females, and subjected to the transplantation of autologous hard palate mucosa. In the same time, flaps were designed and transferred into the defected eyelid soft tissues. All patients were followed up for over 3 months to observe the treatment outcomes.
RESULTS AND CONCLUSION: Three months after surgery, viscous secretions were found in the implanted region and conjunctival sac, which were relieved and eliminated by usage of antibiotic drops. All implanted hard palate mucosa survived within 1 year, neither infections nor falling off occurred, and blood vessels growth into the implant-tissue conjugation that inosculated with the host vessels presenting no rejection. The implants revealed different degrees of shrink in 132 patients, but the eye function was normal. During the hospitalization, some uncomfortable feeling such as eye pain had been relieved, and the wound showed no infections and healed well. During the follow-up, there were eight patients with slight lower eyelid ectropion and three with hypophasis. The length or height difference of both eyelids was within 2 mm, except those who lost eye balls. These results suggest that autologous hard palate mucosa achieve satisfactory outcomes in the eyelid reconstruction and possesses good histocompatibility.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Eyelids, Palate, Hard, Tissue Engineering

CLC Number:

R318

Shi Jun-hu1, Liu Shan1, Bai Ping1, Chu Miao2. Application of autologous hard palate mucosa in the eyelid reconstruction[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(12): 1921-1925.

Figures/Tables 2

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