Flurbiprofen axetil for damage control in rat models of hip fractures: reducing inflammatory responses

doi:10.3969/j.issn.2095-4344.2015.29.003

Abstract

Abstract:

BACKGROUND: Since damage control theory system was founded, this theory in the orthopedics has been applied gradually, especially in elderly hip fracture surgery that reduces the negative impacts due to inflammatory responses.
OBJECTIVE: To explore whether flurbiprofen axetil can reduce inflammatory responses in rats with hip fractures based on the damage control theory.
METHODS: Forty-nine healthy Sprague-Dawley rats weighing 250-300 g were randomly divided into four groups:
control group (n=7), immediate internal fixation group (n=14), flurbiprofen axetil group (n=14), damage control group (n=14). Rats in the control group moved freely in the cages. Rats in the other three groups were intraperitoneally injected with composite anesthetics to make unilateral hip fracture models, and then respectively given internal fixation immediately after fracture, flurbiprofen axetil injection and delayed internal fixation, and delayed internal fixation. Levels of serum C-reactive protein, interleukin-6 and tumor necrosis factor-α were determined and analyzed before fixation, immediately after internal fixation and at 4, 8, 12, 24, 48 hours after internal fixation in different groups.
RESULTS AND CONCLUSION: Postoperative serum levels of C-reactive protein, interleukin-6, tumor necrosis factor-α were all increased in different groups. The level of C-reactive protein reached the peak at 24 hours after internal fixation. Flurbiprofen axetil injection had no significant influence on the level of C-reactive protein in rats with delayed internal fixation (P=0.51). Interleukin-6 levels were still increased at 48 hours after internal fixation, but flurbiprofen axetil reduced the level of interleukin-6 significantly in rats with delayed internal fixation (P < 0.01). The tumor necrosis factor-α level peaked at 4 hours after internal fixation, and flurbiprofen axetil injection could significantly reduce the level of tumor necrosis factor-α in rats with delayed internal fixation (P < 0.01). These findings indicate that flurbiprofen axetil as a new non-steroidal anti-inflammatory drug can reduce the inflammatory response in rats with hip fractures after internal fixation, and also can alleviate the inflammatory response of rats undergoing delayed operation under the guidance of damage control theory.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Flurbiprofen, Hip Fractures, Inflammation, Models, Animal

CLC Number:

R318

Han Ya-jun, Tie Xiao-jia, Hou Yan-jie, Guo Hong-liang, Wang Zhi-zhou, Wang Lian-peng, Yilihamu Tuoheti. Flurbiprofen axetil for damage control in rat models of hip fractures: reducing inflammatory responses[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(29): 4603-4608.

Figures/Tables 4

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