Bone marrow mesenchymal stem cells for repair of cartilage defects

doi:10.3969/j.issn.2095-4344.2015.19.022

Abstract

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells are a kind of non-hematopoietic adult stem cells, mainly distributing in the bone marrow, with strong proliferation and differentiation potential, which has a promising clinical prospect.
OBJECTIVE: To review the latest progress in growth factors and biological scaffolds to promote chondrogenic differentiation of bone marrow mesenchymal stem cells.
METHODS: PubMed and CNKI databases were searched by the first author using key words of “cartilage defects, tissue engineering, biological scaffolds, bone marrow mesenchymal stem cells, cytokines” in English and in Chinese, respectively, to retrieve relevant articles published from 1990 to 2014. Literatures addressing the chondrogenic differentiation of bone marrow mesenchymal stem cells were included, and 51 articles were chosen for further analysis eventually.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells have the potential to differentiate into chondrocytes, which can be induced by many cytokines. Various biological scaffolds act as a carrier for chondrogenic differentiation of bone marrow mesenchymal stem cells. But there are still lots of problems to be solved and in-depth explored clinically.

Key words: Bone Marrow, Mesenchymal Stem Cells, Cytokines, Tissue Scaffolds

CLC Number:

R318

Lu Xian-chuang, Zhang Zhi-feng, Huang Jian. Bone marrow mesenchymal stem cells for repair of cartilage defects[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(19): 3083-3088.

Figures/Tables 2

References

[1] Maegawa N, Kawamura K, Hirose M, et al. Enhancement of osteoblastic differentiation of mesenchymal stromal cells cultured by selective combination of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2). J Tissue Eng Regen Med. 2007;1(4):306-313.

[2] Abdallah BM, Kassem M. Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther. 2008; 15(2):109-116.

[3] Nukavarapu SP, Dorcemus DL. Osteochondral tissue engineering: current strategies and challenges. Biotechnol Adv. 2013;31(5):706-721.

[4] Panseri S, Russo A, Cunha C, et al. Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surg Sports Traumatol Arthrosc. 2012;20(6):1182-1191.

[5] Jones E, McGonagle D. Human bone marrow mesenchymal stem cells in vivo. Rheumatology (Oxford). 2008;47(2): 126-131.

[6] Zhang W, Li Z, Huang Q, et al. Effects of a hybrid micro/nanorod topography-modified titanium implant on adhesion and osteogenic differentiation in rat bone marrow mesenchymal stem cells. Int J Nanomedicine. 2013;8: 257-265.

[7] Jungebluth P, Alici E, Baiguera S, et al. Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study. Lancet. 2011;378 (9808):1997-2004.

[8] Karagianni M, Brinkmann I, Kinzebach S, et al. A comparative analysis of the adipogenic potential in human mesenchymal stromal cells from cord blood and other sources. Cytotherapy. 2013;15(1):76-88.

[9] Sun Z, Wang Y, Gong X, et al. Secretion of rat tracheal epithelial cells induces mesenchymal stem cells to differentiate into epithelial cells. Cell Biol Int. 2012;36(2): 169-175.

[10] Zhao JW, Zhang MR, Ji QY, et al. The role of slingshot-1L (SSH1L) in the differentiation of human bone marrow mesenchymal stem cells into cardiomyocyte-like cells. Molecules. 2012;17(12):14975-14994.

[11] Getgood A, Brooks R, Fortier L, et al. Articular cartilage tissue engineering: today's research, tomorrow's practice. J Bone Joint Surg Br. 2009;91(5):565-576.

[12] Kang SW, Yoo SP, Kim BS. Effect of chondrocyte passage number on histological aspects of tissue-engineered cartilage. Biomed Mater Eng. 2007;17(5):269-276.

[13] Kim HJ, Im GI. Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: greater doses of growth factor are necessary. J Orthop Res. 2009;27(5): 612-619.

[14] 俞猛,于方,付胜良.兔骨髓间充质干细胞体外培养定向诱导分化为软骨细胞[J].中国组织工程研究与临床康复,2011,15(27): 4951-4954.

[15] Frisch J, Venkatesan JK, Rey-Rico A, et al. Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2014;5(4):103.

[16] 欧阳冰,林绵辉,左文建,等.结缔组织生长因子对体外培养的兔关节软骨细胞增殖和表型的影响[J].中国组织工程研究与临床康复, 2009,13(20):3816-3820.

[17] Wu G, Cui Y, Wang YT, et al. Repair of cartilage defects in BMSCs via CDMP1 gene transfection. Genet Mol Res. 2014; 13(1):291-301.

[18] Haleem-Smith H, Calderon R, Song Y, et al. Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells. J Cell Biochem. 2012;113(4):1245-1252.

[19] Steinert AF, Weissenberger M, Kunz M, et al. Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells. Arthritis Res Ther. 2012;14(4): R168.

[20] Neumann AJ, Alini M, Archer CW, et al. Chondrogenesis of human bone marrow-derived mesenchymal stem cells is modulated by complex mechanical stimulation and adenoviral-mediated overexpression of bone morphogenetic protein 2. Tissue Eng Part A. 2013;19(11-12):1285-1294.

[21] de Vries-van Melle ML, Narcisi R, Kops N, et al. Chondrogenesis of mesenchymal stem cells in an osteochondral environment is mediated by the subchondral bone. Tissue Eng Part A. 2014;20(1-2):23-33.

[22] Park MS, Kim YH, Jung Y, et al. In situ recruitment of human BMSCs using chemokines for articular cartilage regeneration. Cell Transplant. 2014 Apr 22. [Epub ahead of print]

[23] Christensen BB, Foldager CB, Hansen OM, et al. A novel nano-structured porous polycaprolactone scaffold improves hyaline cartilage repair in a rabbit model compared to a collagen type I/III scaffold: in vitro and in vivo studies. Knee Surg Sports Traumatol Arthrosc. 2012;20(6):1192-1204.

[24] Hoch E, Schuh C, Hirth T, et al. Stiff gelatin hydrogels can be photo-chemically synthesized from low viscous gelatin solutions using molecularly functionalized gelatin with a high degree of methacrylation. J Mater Sci Mater Med. 2012;23 (11): 2607-2617.

[25] Sharma B, Fermanian S, Gibson M, et al. Human cartilage repair with a photoreactive adhesive-hydrogel composite. Sci Transl Med. 2013;5(167):167ra6.

[26] de Vries-van Melle ML, Tihaya MS, Kops N, et al. Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent. Eur Cell Mater. 2014;27: 112-123.

[27] Spoliti M, Iudicone P, Leone R, et al. In vitro release and expansion of mesenchymal stem cells by a hyaluronic acid scaffold used in combination with bone marrow. Muscles Ligaments Tendons J. 2013;2(4):289-294.

[28] Patrascu JM, Krüger JP, Böss HG, et al. Polyglycolic acid-hyaluronan scaffolds loaded with bone marrow-derived mesenchymal stem cells show chondrogenic differentiation in vitro and cartilage repair in the rabbit model. J Biomed Mater Res B Appl Biomater. 2013;101(7):1310-1320.

[29] Araki S, Imai S, Ishigaki H, et al. Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model. Acta Orthop. 2015;86(1):119-126.

[30] Liu PF, Guo L, Zhao DW, et al. Study of human acellular amniotic membrane loading bone marrow mesenchymal stem cells in repair of articular cartilage defect in rabbits. Genet Mol Res. 2014;13(3):7992-8001.

[31] Zhu S, Zhang B, Man C, et al. Combined effects of connective tissue growth factor-modified bone marrow-derived mesenchymal stem cells and NaOH-treated PLGA scaffolds on the repair of articular cartilage defect in rabbits. Cell Transplant. 2014;23(6):715-727.

[32] Lim CT, Ren X, Afizah MH, et al. Repair of osteochondral defects with rehydrated freeze-dried oligo[poly(ethylene glycol) fumarate] hydrogels seeded with bone marrow mesenchymal stem cells in a porcine model. Tissue Eng Part A. 2013;19(15-16):1852-1861.

[33] Caminal M, Moll X, Codina D, et al. Transitory improvement of articular cartilage characteristics after implantation of polylactide:polyglycolic acid (PLGA) scaffolds seeded with autologous mesenchymal stromal cells in a sheep model of critical-sized chondral defect. Biotechnol Lett. 2014;36(10): 2143-2153.

[34] Wu G, Cui Y, Ma L, et al. Repairing cartilage defects with bone marrow mesenchymal stem cells induced by CDMP and TGF-β1. Cell Tissue Bank. 2014;15(1):51-57.

[35] Liu S, Wu J, Liu X, et al. Osteochondral regeneration using an oriented nanofiber yarn-collagen type I/hyaluronate hybrid/TCP biphasic scaffold. J Biomed Mater Res A. 2015; 103(2):581-592.

[36] Childs A, Hemraz UD, Castro NJ, et al. Novel biologically-inspired rosette nanotube PLLA scaffolds for improving human mesenchymal stem cell chondrogenic differentiation. Biomed Mater. 2013;8(6):065003.

[37] Deng J, She R, Huang W, et al. A silk fibroin/chitosan scaffold in combination with bone marrow-derived mesenchymal stem cells to repair cartilage defects in the rabbit knee. J Mater Sci Mater Med. 2013;24(8):2037-2046.

[38] Berninger MT, Wexel G, Rummeny EJ, et al. Treatment of osteochondral defects in the rabbit's knee joint by implantation of allogeneic mesenchymal stem cells in fibrin clots. J Vis Exp. 2013;(75):e4423.

[39] Gupta PK, Das AK, Chullikana A, et al. Mesenchymal stem cells for cartilage repair in osteoarthritis. Stem Cell Res Ther. 2012;3(4):25.

[40] Inagaki Y, Kitamura N, Kurokawa T, et al. Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study. BMC Musculoskelet Disord. 2014;15:320.

[41] Iwamoto M, Ohta Y, Larmour C, et al. Toward regeneration of articular cartilage. Birth Defects Res C Embryo Today. 2013; 99(3):192-202.

[42] Orth P, Rey-Rico A, Venkatesan JK, et al. Current perspectives in stem cell research for knee cartilage repair. Stem Cells Cloning. 2014;7:1-17.

[43] Via AG, Frizziero A, Oliva F. Biological properties of mesenchymal Stem Cells from different sources. Muscles Ligaments Tendons J. 2012;2(3):154-162.

[44] Rocha B, Calamia V, Casas V, et al. Secretome analysis of human mesenchymal stem cells undergoing chondrogenic differentiation. J Proteome Res. 2014;13(2):1045-1054.

[45] 童培建,厉驹,瞿杭波,等.经皮自体骨髓间充质干细胞移植治疗四肢骨折骨不连[J].中华创伤杂志,2007,23(7):499-501.

[46] Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M, et al. Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Arch Iran Med. 2007;10(4):459-466.

[47] Delaine-Smith RM, Reilly GC. Mesenchymal stem cell responses to mechanical stimuli. Muscles Ligaments Tendons J. 2012;2(3):169-180.

[48] Skowroński J, Skowroński R, Rutka M. Large cartilage lesions of the knee treated with bone marrow concentrate and collagen membrane--results. Ortop Traumatol Rehabil. 2013; 15(1):69-76.

[49] Suhaeb AM, Naveen S, Mansor A, et al. Hyaluronic acid with or without bone marrow derived-mesenchymal stem cells improves osteoarthritic knee changes in rat model: a preliminary report. Indian J Exp Biol. 2012;50(6):383-390.

[50] Tan SL, Ahmad TS, Selvaratnam L, et al. Isolation, characterization and the multi-lineage differentiation potential of rabbit bone marrow-derived mesenchymal stem cells. J Anat. 2013;222(4):437-450.

[51] Takazawa K, Adachi N, Deie M, et al. Evaluation of magnetic resonance imaging and clinical outcome after tissue-engineered cartilage implantation: prospective 6-year follow-up study. J Orthop Sci. 2012;17(4):413-424.