Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (48): 9059-9063.doi: 10.3969/j.issn.2095-4344.2012.48.025

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Research progress of the wear particles-induced aseptic prosthesis loosening

Li Hai-ya, Zha Zhen-gang   

  1. Department of Orhtopedics, First Afiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China
  • Received:2012-02-26 Revised:2012-04-09 Online:2012-11-25 Published:2013-03-14
  • Contact: Zha Zhen-gang, Professor, Doctoral Supervisor, Chief physician, Department of Orhtopedics, First Afiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China zhzgg@vip.163.com
  • About author:Li Hai-ya★, Studying for master’s degree, Department of Orhtopedics, First Afiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China 312201526@qq.com

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Abstract:

BACKGROUND: Studies have shown that the wear particle-induced periprosthesis osteolysis is the main reason leading to aseptic loosening of prosthesis.
OBJECTIVE: To review the research progress of the wear particle-induced aseptic prosthesis loosening in molecular biology.
METHODS: A computer-based search was performed on the CNKI database and PubMed database from January 1991 to March 2012 for the articles related to the wear particles of prosthesis. The key words of “arthroplasty, wear particles, loosening of the prosthesis” in English and Chinese were used to search the articles in the title and the abstract. Finally, a total of 30 artilces were included to review.
RESULTS AND CONCLUSION: Aseptic loosening of the prosthesis is the main reason for the failure of the surgery after artificial joint replacement, and the wear particles play an important role during the process. The synthesis on the research of cytokines and signal transduction pathways provides a theoretical basis for prevention and drug treatment of prosthesis aseptic loosening. However, prosthesis aseptic loosening can be influenced by a variety of factors, prevention should be the overall focused and comprehensive studied which can provide direction for the prevention of prosthesis loosening .

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