Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (48): 9064-9068.doi: 10.3969/j.issn.2095-4344.2012.48.026

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Usage of statins for the prevention and treatment of aseptic loosening of artificial joint

Wang Jing, Tian Jing   

  1. Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Received:2012-02-26 Revised:2012-04-05 Online:2012-11-25 Published:2013-03-14
  • Contact: Tian Jing, Master, Associate chief physician, Professor, Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@yahoo.com.cn
  • About author:Wang Jing, Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China iris20088888@126.com

Abstract:

BACKGROUND: The most significant factor that affects the life span of joint prosthesis is the artificial joint aseptic loosening. Statins were found that it can stable artificial jointaseptic loosening.
OBJECTIVE: To review from three areas, including pharmacological mechanism, clinical trials and adverse reactions, in order to provide reference for clinical practice of statins on the prevention of artificial joint aseptic loosening.
METHODS: A computer-based online search of PubMed database and CNKI database between 2007 and 2011 was performed to search related articles with the key words of “statins, artificial joint, aseptic loosening, prosthesis, osteolysis” in English or Chinese. Literatures related to statins for the prevention of artificial joint aseptic loosening were selected, and for the articles in the same field, we preferred the ones published recently or in authorize journals. A total of 167 literatures were primarily selected, and 33 documents were involved for summary according to inclusion criteria.
RESULTS AND CONCLUSION: Statins can promote the formation of new bone around prosthesis, enhance the three-point bending strengths and stabilize the structure of bone around the prosthesis. However, some experiments show that high doses of simvastatin might be harmful in multiple myeloma patients, as it can results a inflammation in certain concentration. As a new drug for preventing artificial jointaseptic loosening, further studies to determine the best drug threshold, administration methods and value of human bone regeneration are very important.

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