Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7777-7781.doi: 10.3969/j.issn.2095-4344.2012.41.035

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Umbilical cord blood stem cell transplantation combined with mouse neural growth factor application and physical rehabilitation therapy for infantile cerebral palsy

Xing Li-he1, Zhang Li-xin1, Zhang Li-li1, Sun Li-fang2, Dong Yan-hui1, Liu Ying1, Guo Li-jie1   

  1. 1Stem Cell Therapy Center, the 261 Hospital of Chinese PLA, Beijing 100094, China
    2Hospital of Hebei University of Technology, Tianjin 300130, China
  • Received:2012-01-01 Revised:2012-02-29 Online:2012-10-07 Published:2012-10-07
  • Contact: Xing Li-he, Stem Cell Therapy Center, the 261 Hospital of Chinese PLA, Beijing 100094, China xinglh@163.com
  • About author:Xing Li-he☆, M.D., Associate professor, Stem Cell Therapy Center, the 261 Hospital of Chinese PLA, Beijing 100094, China

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Abstract:

BACKGROUND: Umbilical cord blood stem cell transplantation is an optimal therapeutic method of nervous system diseases.
OBJECTIVE: To investigate the clinical efficacy of umbilical cord blood stem cell transplantation combined with mouse neural stem cell application and physical rehabilitation therapy for infantile cerebral palsy.
METHODS: 90 patients with cerebral palsy were randomly and evenly divided into three groups: umbilical cord blood stem cells group (umbilical cord blood mesenchymal stem cells + mouse neural growth factor + physical rehabilitation therapy), routine treatment group (mouse neural growth factor + physical rehabilitation therapy) and control group (no effective treatment).
RESULTS AND CONCLUSION: Prior to treatment, there was no significant difference in gross motor function measure (GMFM) scores of each functional item among three groups (P > 0.05). Compared with prior to treatment, at 3 months after treatment, the GMFM scores of A, B, D items were significantly increased in the umbilical cord blood stem cells group and routine treatment group (P < 0.05); GMFM scores of A, B functional items were significantly higher in the umbilical cord blood stem cells group than in the routine treatment group (P < 0.05); there was no significant difference in GMFM scores of each functional item in the control group (P > 0.05). These results showed that umbilical cord blood mesenchymal stem cell transplantation combined with mouse neural stem cell application and physical rehabilitation therapy exhibits better curative effects in treatment of infantile cerebral palsy than mouse neural growth factor application combined with physical rehabilitation therapy.

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