Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (25): 4697-4700.doi: 10.3969/j.issn.1673-8225.2012.25.028

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Preparation of porous bio-ceramic beta-tricalcium phosphate scaffolds by freeze-drying technique

Wang Xue-tao1, Li Jing1, Zuo Kai-hui2, Zeng Yu-ping2, Zhang Bao-wei1   

  1. 1Department of Dental Restoration, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China;
    2Research Group of Advanced Environmental Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
  • Received:2011-11-03 Revised:2011-12-08 Online:2012-06-17 Published:2013-11-04
  • Contact: Zhang Bao-wei, Professor, Department of Dental Restoration, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China baoweizhang18@ msn.com
  • About author:Wang Xue-tao★, Studying for master’s degree, Department of Dental Restoration, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China wangxuetao198558@126.com

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Abstract:

BACKGROUND: There are many factors which can influence the microstructures and properties of bio-ceramic scaffolds prepared by the freeze-drying process, such as the slurry solid loading, freezing rate, sintering conditions, and so on.
OBJECTIVE: To prepare bio-ceramic β-tricalcium phosphate (β-TCP) scaffolds with different morphologies and porosities by adjusting the content of the slurries and analyze the influence factors.
METHODS: The β-TCP scaffolds with different morphologies and porosities were prepared, and then bio-ceramic β-TCP scaffolds were obtained through freezing, drying and heating. Phase analysis, microstructure of the section and porosity of bio-ceramic β-TCP scaffolds were detected by X-ray diffraction, scanning electron microscopy and Archimedes drainage method, respectively.
RESULTS AND CONCLUSION: The diffraction peak position of the scaffolds was identical with the standard β-TCP; the scaffolds without polyvinyl alcohol had the macroscopic lamellar pores and porous ceramic walls, and as the solid longing of slurry was increasing, the pore size and the porosity decreased; scaffolds containing polyvinyl alcohol: the lamellar pores gradually changed into the interconnected three-dimensional reticulate pores, and the porosity was improved because of the addition of polyvinyl alcohol. It is indicated the morphology and porosity of the bio-ceramic scaffolds prepared using the freeze-drying process can be controlled by adjusting the content of the slurries.

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