Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (25): 4701-4705.doi: 10.3969/j.issn.1673-8225.2012.25.029

Previous Articles     Next Articles

10.3969/j.issn.1673-8225.2012.25.029

You Zuo-xiang1, 2, Yang Qin-zheng1, Yue Zhan-guo2, Ma Guang-hui2, Wei Wei2   

  1. 1Department of Food and Bioengineering, Shandong Polytechnic University, Jinan 250353, Shandong Province, China;
    2National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2011-10-09 Revised:2011-11-18 Online:2012-06-17 Published:2013-11-04
  • Contact: Yang Qin-zheng, Doctor, Associate professor, Master’s supervisor, Department of Food and Bioengineering, Shandong Polytechnic University, Jinan 250353, Shandong Province, China yangqinzheng@ sina.com Wei Wei, Doctor, Assistant researcher, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China weiwei@ home.ipe.ac.cn
  • About author:You Zuo-xiang★, Studying for master’s degree, Department of Food and Bioengineering, Shandong Polytechnic University, Jinan 250353, Shandong Province, China; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China xiang85518@ 126.com

PDF

850

Abstract:

BACKGROUND: The non-specific distribution of anticancer drugs in vivo may cause serious side effects and low bioavailability. Drug carriers with the active targeting abilities can solve these problems.
OBJECTIVE: To review the recent studies on carrier preparation for anticancer drug delivery and summarize different types of active targeting strategies for drug carrier.
METHODS: A computer-based online search was performed for articles published from 2004 to 2011 in Web of Knowledge database with the English key words that closely related to various active targeting strategies, such as “tumor, drug carrier, active targeting”. Totally 58 articles were retrieved, and finally 26 of them met the requirement.
RESULTS AND CONCLUSION: Active targeting strategy is the first problem need to consider and the most important part in designing anticancer drug carriers. It contributes to the actual effect of drug delivery and bioavailability of drug. Drug carriers with various active targeting abilities can carry antitumor drugs to tumor sites and significantly reduced the non-specific distribution of drugs in vivo in order to decrease the side effects and enhanced bioavailability.

CLC Number: