Abstract:

BACKGROUND: Our previous studies have confirmed that collagen/hyaluronic acid membrane has good mechanical properties and histocompatibility.
OBJECTIVE: To explore the biological properties of collagen/hyaluronic acid membrane and gelatin sponge scaffold.
METHODS: The collagen/hyaluronic acid membrane was constructed by compound cross linking method. The mechanical property of the collagen/hyaluronic acid membrane and gelatin sponge scaffold was detected. The scaffold materials were implanted subcutaneously in rabbits; the in vivo degradation and mechanical properties were evaluated at 2, 4, 6, 8 and 12 weeks after implantation.
RESULTS AND CONCLUSION: Collagen/hyaluronic acid membrane was constructed successfully. Collagen/hyaluronic acid membrane had a better toughness and tensile strength while the mechanical property of gelatin sponge was not ideal. The in vivo degradation of the two materials was compatible with the tissue reactions of biomaterials. Complete degradation of the collagen/hyaluronic acid membrane could be done within 12 weeks, while the gelatin sponge within 6 weeks. The adhesion rate between the collagen/hyaluronic acid membrane and smooth muscle cells was high; the cell proliferation and the metabolic status were good. The adhesion rate and proliferation rate of the gelatin sponge was relatively low. These findings indicate that gelatin sponge has better biological properties.