Abstract:

BACKGROUND: Adult stem cells can differentiate into all kinds of cell type. Under special conditions, adult stem cells can differentiate into osteoblasts, chondrocytes, adipocytes, muscle cells and neural cells to replace and to repair damaged tissues and cells, to achieve functional recovery purposes.
OBJECTIVE: To observe the effect of umbilical cord blood mesenchymal stem cells (UCB-MSCs) therapy in hypoglycemic coma combined with hypoxic ischemic encephalopathy.
METHODS: One case of hypoglycemic coma combined with hypoxic ischemic encephalopathy and pulmonary infection was admitted. This patient received a combined treatment, including anti-free radical, nerve-nurturing, consciousness-regaining, anti-infective therapy, rehabilitation and physiotherapy. At the same time, we also gave him the UCB-MSCs therapy by intravenous infusion. The recovery of consciousness, electroencephalogram, activity of daily living and follow-up results were observed during hospital stay.
RESULTS AND CONCLUSION: One month later, the patient’s motor and cognitive function recovered better. Electroencephalogram was rechecked. The a wave was observed. The activity of daily living scored 50 points. Seventy days later, follow-up showed that no adverse reaction was detectable, which suggested that stem cell therapy was safe in short period. These indicated that UCB-MSCs for hypoglycemic coma combined with hypoxic ischemic encephalopathy are safe and effective.