Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2805-2808.doi: 10.3969/j.issn.1673-8225.2011.15.035

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Role of SDF-1/CXCR4 signaling pathway in pathogenesis of osteoarthritis

Li Xiao-lin, Li Yan-lin, Ma Ke, Cao Bin, Wang Guo-liang, Yang Guang, Xu Peng   

  1. Department of Orthopedics, the First Affiliated Hospital of Kunming Medical College, Kunming  650031, Yunnan Province, China
  • Received:2010-10-19 Revised:2011-03-05 Online:2011-04-09 Published:2013-11-06
  • Contact: Li Yan-lin, Professor, Chief physician, Doctoral supervisor, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China yanlinli1969@yahoo.com.cn
  • About author:Li Xiao-lin★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China lixiaolinloveyou83@ 126.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860286*

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Abstract:

BACKGROUND: The pathogenesis of osteoarthritis (OA) is very complex, the prevention and treatment of OA is a medical challenge, and the signaling pathway related to OA is becoming the hot spot of current researches. The targeted therapy may be the key to treat OA.
OBJECTIVE: To discuss the role of SDF-1/CXCR4 signaling pathway in many diseases and the pathogenesis of OA, and to provide the basis of targeted therapy on OA.
METHODS: CBM and PubMed were retrieved by computer using key words of “SDF-1; CXCR4 signaling pathway; Osteoarthritis” both in Chinese and English, with the method of subject index combined with limited index. The papers which included the two themes were accepted, and those which had old and duplicate contents were excluded.
RESULTS AND CONCLUSIONS: Of 2 147 retrieved articles, only 32 papers were involved in result analysis. SDF-1/CXCR4 signaling pathway, with its important role in many diseases, is becoming the research focus of current medical associates. SDF-1/CXCR4 signaling pathway possibly has important effect on OA. The targeted therapy on OA may be the key of the treatment of OA.

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