Resting-state functional magnetic resonance imaging evaluation of the brain’s default mode network in patients with sleep bruxism

doi:10.3969/j.issn.2095-4344.2999

Abstract

Abstract: BACKGROUND: Sleep bruxism is a common oral accessory function, but the etiology is not yet clear. A psychological questionnaire survey on patients with nocturnal molars reveals that sleep bruxism is related to psychological factors, but the specific relationship and mechanism between them are not clear.
OBJECTIVE: To analyze the changes of brain’s default mode network (DMN) in patients with sleep bruxism and to investigate the DMN status of patients with sleep bruxism.
METHODS: From November 2018 to May 2019, 20 patients with sleep bruxism (sleep bruxism group) diagnosed by polysomnography and 20 age-, gender-, and education-matched asymptomatic adults (control group) were recruited in the study. Brain resting-state functional MRI data were collected on a 3.0T scanner during 20:00 to 23:00. The MRI data were analyzed using independent component analysis method to extract the component of DMN. The one-sample t-test was used to make a network component template, and then the two-sample t-test used to compare the DMN components between the two groups.
RESULTS AND CONCLUSION: Compared with asymptomatic controls, patients with sleep bruxism showed a significantly weaker functional connectivity of the precuneus within the DMN (t=-3.319, P < 0.05), indicating that patients with sleep bruxism show abnormal functional connectivity within the DMN at brain-resting state.

Key words: functional MRI, resting state, default mode network, precuneus, polysomnography, psychology, oral cavity, sleep bruxism

CLC Number:

Jing Huimin, Yu Wenjuan, Wang Sijia, Chen Cong, Li Yifan, Wang Yonglan, Li Xin, Zhang Juan, Liang Meng. Resting-state functional magnetic resonance imaging evaluation of the brain’s default mode network in patients with sleep bruxism[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(5): 685-689.

Figures/Tables 7

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