Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (5): 673-681.doi: 10.3969/j.issn.2095-4344.2440
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Cao Guolong1, Tian Faming2, Liu Jiayin3
Received:
2019-06-26
Revised:
2019-06-29
Accepted:
2019-08-07
Online:
2020-02-18
Published:
2020-01-08
Contact:
Cao Guolong, Department of Orthopedics, Worker’s Hospital of Tangshan, Tangshan 063000, Hebei Province, China
About author:
Cao Guolong, MD, Associate chief physician, Department of Orthopedics, Worker’s Hospital of Tangshan, Tangshan 063000, Hebei Province, China
Supported by:
CLC Number:
Cao Guolong, Tian Faming, Liu Jiayin. Lovastatin combined with insulin effects on fracture healing in rat models of bilateral ovariectomized type 2 diabetic mellitus[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(5): 673-681.
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2.7 各组大鼠组织形态学评分 苏木精-伊红染色切片观察可见,正常对照组骨折端已出现较多的骨性骨痂,而软骨组织相对较少,局部可见骨性骨痂连接骨折端;骨质疏松骨折组骨折端仍可见较多软骨组织及纤维组织,而骨性骨痂相对较少,未见骨性骨痂连接骨折端;胰岛素治疗组和胰岛素联合洛伐他汀组虽然未见明显骨性骨痂连接骨折端,但与骨质疏松骨折组相比,其内骨性骨痂相对较多,而只有少量纤维组织存在,余下部分被软骨组织所填充。组织形态学评分结果分析显示,骨质疏松骨折组、胰岛素治疗组和胰岛素联合洛伐他汀组显著低于正常对照组(P < 0.05),胰岛素治疗组和胰岛素联合洛伐他汀组显著高于骨质疏松骨折组(P < 0.05),胰岛素治疗组和胰岛素联合洛伐他汀组间无显著差异(图7)。"
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