Application status of small interfering RNA in spinal cord injury

doi:10.3969/j.issn.2095-4344.2017.36.026

Abstract

Abstract:

BACKGROUND: The connection between high-level central nervous system and spinal cord and peripheral nerve under injury level is blocked by traumatic spinal cord injury, and the whole function of the body is thereby influenced. The loss of motor function and feeling both severely affect the patient’s life quality in views of physiology, psychology, function and social economics. RNA interference is an effective method to silence target genes, which provides a new treatment strategy for spinal cord injury.
OBJECTIVE: To explore the application status of RNA interference in spinal cord injury.
METHODS: PubMed and CNKI databases were retrieved using the keywords of “RNA interference, RNAi, spinal cord injury” in English and Chinese, respectively. The articles addressing the application of RNA interference in spinal cord injury were collected and reviewed.
RESULTS AND CONCLUSION: Totally 44 articles were enrolled. It is urgent to find a new way to treat spinal cord injury. Compared with the traditional gene silencing technology, RNA interference owing to high specificity, high efficiency, high stability and high penetrability is considered to be a new direction for the studies on the pathogenesis and treatment of spinal cord injury.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Spinal Cord Injuries, RNA Interference, RNA, Small Interfering, Tissue Engineering

CLC Number:

R318

Zhao Jun, Xin Hong-jie, Xue Hui-qin, Zang Yuan-tong, Yan Jin-yu, Li Jian-feng. Application status of small interfering RNA in spinal cord injury[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(36): 5892-5897.

Figures/Tables 2

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